{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:21:28Z","timestamp":1760300488654,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have investigated the developmental prognosis of very\u2010low\u2010birthweight (VLBW) infants with congenital heart diseases (CHDs). This study aimed to determine the mortality and morbidity, including the developmental prognosis, of VLBW infants with CHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center, retrospective cohort study included VLBW infants admitted to the neonatal intensive care unit from January 2006 to December 2011. Perinatal records were reviewed for CHD diagnosis, treatment details, comorbidities, mortality, and long\u2010term neurodevelopmental outcomes. The characteristics and neurological developmental quotients at around the age of 3\u00a0years were compared among the following three groups of VLBW infants with CHDs: biventricular circulation without intervention (without surgery), biventricular circulation with intervention (catheter intervention or one\u2010stage surgery), and single\u2010ventricular circulation (Fontan\u2010type multiple\u2010stage surgery).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among a total of 449 VLBW infants admitted during this period, 45 (10.0%) infants had CHDs, including 25 infants with congenital abnormalities (chromosomal abnormalities and\/or multiple anomalies). All 13 infants who died before discharge had congenital abnormalities. The incidence rates of comorbidities were not higher in VLBW infants with CHDs than in those without CHDs. The developmental quotients of the no\u2010surgery, catheter intervention or one\u2010stage surgery, and Fontan\u2010type multiple\u2010stage surgery groups were 87.2\u00a0\u00b1\u00a010.9, 91.3\u00a0\u00b1\u00a04.7, and 63.7\u00a0\u00b1\u00a08.6, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The neurological development at around the age of 3\u00a0years in VLBW infants with biventricular circulation was in the borderline\u2010to\u2010normal range; however, that in infants with single\u2010ventricular circulation was poor. Further studies are needed to comprehend the neurological development of VLBW infants with CHDs better.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14562","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T20:16:51Z","timestamp":1606594611000},"page":"806-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical features of very\u2010low\u2010birthweight infants with congenital heart disease"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7342-3635","authenticated-orcid":false,"given":"Hiroko","family":"Tomotaki","sequence":"first","affiliation":[{"name":"Department of Neonatology Kanagawa Children\u2019s Medical Center  Kanagawa Japan"},{"name":"Department of Pediatrics Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-9907","authenticated-orcid":false,"given":"Katsuaki","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children\u2019s Medical Center  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Tomotaki","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children\u2019s Medical Center  Kanagawa Japan"},{"name":"Department of Pediatrics Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Shimokaze","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children\u2019s Medical Center  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki\u2010Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kanagawa Children\u2019s Medical Center  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyoshi","family":"Kawataki","sequence":"additional","affiliation":[{"name":"Department of Neonatology Kanagawa Children\u2019s Medical Center  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"issue":"72","key":"e_1_2_7_2_1","first-page":"531","article-title":"Trends in morbidity and mortality among very\u2010low\u2010birth\u2010weight infants from 2003 to 2008 in Japan","volume":"2012","author":"Kusuda S","year":"2003","journal-title":"Pediatr. 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