{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:21:10Z","timestamp":1789348870128,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to explore the association between maternal allergies and preterm birth by different total immunoglobulin E (IgE) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of 81\u00a0791 pregnant women from the Japan Environment and Children\u2019s Study, a prospective birth cohort, were used. Maternal allergic diseases, including a history of bronchial asthma (BA), atopic dermatitis (AD), and allergic rhinitis (AR), were obtained by self\u2010administered questionnaires. Total serum IgE levels were measured at the first trimester and obstetrical outcomes from medical records transcripts were analyzed. The association between maternal allergic disease and obstetric outcome, including threatened abortion, preterm labor, early preterm birth (22\u201333\u00a0weeks), and late preterm birth (34\u201336\u00a0weeks), were examined by logistic regression. Subgroup analyses were performed by IgE level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal BA and AR were associated with an increased risk of threatened abortion and preterm labor, but high total IgE level was associated with a decreased risk of preterm labor. There was little difference in associations between allergic disease and threatened abortion and preterm labor by total IgE levels. Although there was no significant association between allergic disease and preterm birth, if total IgE was high, AR was significantly associated with a decreased risk of early preterm birth (adjusted odds ratio, 0.60; 95% confidence interval 0.43\u20130.86). There was significant evidence for differences associated with total IgE levels (<jats:italic>P<\/jats:italic>\u2010values for the interaction of the effects of AD and AR on early preterm birth were 0.039 and 0.015, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The effect of allergy on preterm birth might differ depending on the total IgE level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14635","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T08:23:41Z","timestamp":1612599821000},"page":"1026-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between preterm birth and maternal allergy considering IgE level"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9712-889X","authenticated-orcid":false,"given":"Reiji","family":"Kojima","sequence":"first","affiliation":[{"name":"Department of Health Sciences School of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7369-155X","authenticated-orcid":false,"given":"Hiroshi","family":"Yokomichi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences School of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Health Sciences School of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadao","family":"Ooka","sequence":"additional","affiliation":[{"name":"Department of Health Sciences School of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Health Sciences School of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Center for Birth Cohort Studies University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Center for Birth Cohort Studies University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zentaro","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Department of Health Sciences School of Medicine University of Yamanashi Yamanashi Japan"},{"name":"Center for Birth Cohort Studies University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Japan Environment and Children's Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-017-0875-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-017-0157-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03055.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12154"},{"key":"e_1_2_9_7_1","article-title":"Association of maternal history of allergic features with preterm pregnancy outcomes in the Japan Environment and Children\u2019s Study","author":"Saito M","year":"2021","journal-title":"Int. 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