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Electroclinical \u201cuncoupling\u201d also adds to the diagnostic challenge. Reliable diagnosis requires additional tools; continuous electroencephalogram (EEG) monitoring is the gold standard for diagnosis of neonatal seizures. Certain high\u2010risk neonatal populations with known brain injury, such as stroke or hypoxic\u2010ischemic encephalopathy, are most likely to benefit from continuous EEG. Studies have shown that risk stratification for continuous EEG has positive impact on care, including rapid and accurate diagnosis and treatment of neonatal seizures, which leads to reduced use of antiseizure medicines and length of hospital stay. This review describes common clinical manifestations of neonatal seizures, and clinical situations in which EEG monitoring to screen for seizures should be considered.<\/jats:p>","DOI":"10.1111\/ped.14654","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T06:42:14Z","timestamp":1613630534000},"page":"631-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical manifestations of neonatal seizures"],"prefix":"10.1111","volume":"63","author":[{"given":"Thuy","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Neurology Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-5567","authenticated-orcid":false,"given":"Courtney J.","family":"Wusthoff","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics Stanford University 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