{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T18:56:00Z","timestamp":1775588160564,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["15ZR1404300"],"award-info":[{"award-number":["15ZR1404300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to assess the efficacy of different initial intravenous immunoglobulin (IVIG) regimens in Kawasaki disease (KD) patients to find more cost\u2010effective therapy options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter, open\u2010label, blind\u2010endpoint randomized controlled trial was conducted from January 2014 to December 2015. Patients with KD, within 10\u00a0days of illness, were randomly assigned to receive different IVIG regimens (Group A, 2\u00a0g\/kg once; Group B, 1\u00a0g\/kg for 2 consecutive days; Group C, 1\u00a0g\/kg once) and aspirin 30mg\/kg\/d. Primary outcomes included hours to defervescence and development of coronary artery lesions during the study period. Major secondary outcomes included total fever days, total dose of IVIG, changes of laboratory data, length of stay, and hospitalization expenses. (ClinicalTrials.gov: NCT02439996).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 404 patients underwent randomization. No difference was found in the outcomes of defervescence among three groups at 6, 12, 24, and 36\u00a0hours after completion of initial IVIG infusion. There were no differences in the incidence of coronary artery lesions during the study period (at week 2, month 1, month 3, and month 6 of illness), changes of laboratory data, total fever days, and length of stay. Group C patients had the lowest total dose of IVIG (mean: 1.2 vs 2.2 vs 2.1\u00a0g\/kg; <jats:italic>P<\/jats:italic> &lt; 0.001) and hospitalization expenses (mean: 8443.8 vs 10798.4 vs 11011.4 Chinese Yuan; <jats:italic>P<\/jats:italic> &lt; 0.001) than other two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A single dose of 1g\/kg IVIG is a low\u2010cost treatment with the same efficacy as 2\u00a0g\/kg IVIG and can be an option for the initial therapy of KD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14656","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T14:52:55Z","timestamp":1613659975000},"page":"757-763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Randomized trial of different initial intravenous immunoglobulin regimens in Kawasaki disease"],"prefix":"10.1111","volume":"63","author":[{"given":"Lan","family":"He","sequence":"first","affiliation":[{"name":"Pediatric Heart Center Children\u2019s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center Children\u2019s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Children\u2019s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Shanghai Children\u2019s Hospital of Shanghai Jiaotong University Shanghai 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chu","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center Children\u2019s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center Children\u2019s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuecun","family":"Liang","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center Children\u2019s Hospital of Fudan University, National Children's Medical Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuna","family":"Sun","sequence":"additional","affiliation":[{"name":"Pediatric Heart Center Children\u2019s Hospital of Fudan University, National Children's Medical 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