{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:03:55Z","timestamp":1790424235559,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Weight gain is an important adverse effect of valproate (VPA) therapy. A number of mechanisms have been proposed for its pathophysiology. The aim of the present study is the evaluation of insulin, leptin and lipid levels in epileptic children on treatment with VPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty epileptic children treated with VPA, and 20 age\u2013sex\u2010matched healthy children, were enrolled in this study. Blood samples were taken and the body mass index was calculated for all of the subjects. Serum insulin, leptin, and lipid levels were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Leptin levels were significantly higher in the patient group (<jats:italic>P<\/jats:italic> = 0.009) whereas body mass index values were comparable. There was a positive correlation between leptin and body mass index among both patient (<jats:italic>r<\/jats:italic> = 0.464, <jats:italic>P<\/jats:italic> = 0.01) and control groups (<jats:italic>r<\/jats:italic> = 0.734, <jats:italic>P<\/jats:italic> = 0.0001). Total cholesterol and low\u2010density lipoprotein (LDL) cholesterol levels were lower in VPA\u2010treated epileptic children than the control group (<jats:italic>P<\/jats:italic> = 0.008; <jats:italic>P<\/jats:italic> = 0.003, respectively). No significant difference was determined in insulin levels between the two groups. A negative correlation was observed between plasma VPA level and total cholesterol and LDL cholesterol levels in the patient group (<jats:italic>r<\/jats:italic> = \u22120.380, <jats:italic>P<\/jats:italic> = 0.03, <jats:italic>r<\/jats:italic> = \u22120.474, <jats:italic>P<\/jats:italic> = 0.008, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated higher leptin levels in the patient group despite similar BMI values. Hence, it seems likely that VPA causes leptin resistance. Unlike other anti\u2010epileptics, VPA does not produce an increase in serum cholesterol levels. On the contrary, lower levels of total and LDL cholesterol levels in VPA\u2010receiving patients have been observed in our study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14674","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:24:26Z","timestamp":1614817466000},"page":"1351-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effects of valproate on serum leptin, insulin, and lipid levels in epileptic children"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1987-507X","authenticated-orcid":false,"given":"Huseyin","family":"Kilic","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology Cerrahpasa School of Medicine Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atalay","family":"Demirel","sequence":"additional","affiliation":[{"name":"Division 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