{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:16:33Z","timestamp":1772572593488,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have examined the effect of low\u2010grade intraventricular hemorrhage (IVH) on the white matter in the cerebellum and its association with neurodevelopment. We evaluated cerebellar white matter at term\u2010equivalent age (TEA) in preterm infants with low\u2010grade IVH. Furthermore, we assessed neurodevelopmental outcomes at 3\u2009years of age to examine the influence of low\u2010grade IVH on neurodevelopment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen infants with low\u2010grade IVH and 26 without IVH, born at &lt;30\u2009weeks\u2019 postmenstrual age (PMA), were enrolled in this study. Diffusion tensor imaging (DTI) parameters, including fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the middle and superior cerebellar peduncles (SCP), were measured. Neurodevelopmental outcomes at three years of age were assessed and the correlation between DTI parameters and developmental quotient (DQ) was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preterm infants with IVH showed lower FA values (<jats:italic>P<\/jats:italic> &lt; 0.01) and higher ADC values (<jats:italic>P<\/jats:italic> &lt; 0.05) in the SCP at TEA than the no\u2010IVH group. Lower Postural\u2010Motor and Cognitive\u2010Adaptive DQ at 3\u2009years of age were observed in the IVH compared to the no\u2010IVH group. A significant correlation between the FA values in the SCP at TEA and the Posture\u2010Motor DQ was observed at three years of age (<jats:italic>P<\/jats:italic> = 0.043, <jats:italic>r<\/jats:italic> = 0.50).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that low\u2010grade IVH in preterm infants affects the SCP at TEA and that impaired cerebellar white matter correlates with poor motor development at three years of age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14691","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T23:04:05Z","timestamp":1615503845000},"page":"1327-1333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Low\u2010grade IVH in preterm infants causes cerebellar damage, motor, and cognitive impairment"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2370-4345","authenticated-orcid":false,"given":"Satoshi","family":"Sakaue","sequence":"first","affiliation":[{"name":"Department of Pediatrics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuji","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Radiology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui","family":"Zen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takenori","family":"Tozawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Chiyonobu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Radiology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of 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