{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:31Z","timestamp":1753879351184,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Furosemide is an off\u2010label drug, frequently used as a diuretic in neonates with oliguria and\/or edema. Its clearance in preterm neonates is lower than in term neonates or children. We aimed, herein, to clarify furosemide clearance (CL) in very preterm (VP) neonates (&lt;28\u2009weeks\u2019 gestation) within the first 2\u2009weeks of life and identify the factors predictive of the pharmacokinetics (PK) parameters, such as CL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Furosemide was administered at 0.5 or 1\u2009mg\/kg in a 0.5\u2010h infusion via a syringe pump; blood samples were drawn from an artery or vein after the intravenous injection. The serum furosemide concentration was measured using high\u2010performance liquid chromatography. The PK parameters were then analyzed using Bayesian estimation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen blood samples were obtained from 10 VP neonates after intravenous injection. The mean postconceptional age and mean postnatal days at exposure to furosemide were 26.9\u2009weeks and 7.1\u2009days, respectively. The estimated mean CL was 16.5\u2009mL\/kg\/h. The mean distribution volume (Vd) and elimination half\u2010life (t1\/2) were 0.37\u2009L\/kg and 15.3\u2009h, respectively. Furosemide CL was negatively associated with serum creatinine (SCr) [CL = 84.2 \u2013 67.1 \u00d7 SCr (mg\/dL)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Very preterm neonates within the first 2\u2009weeks of life had a higher CL than subjects in other preterm neonatal studies. The SCr level was the sole parameter influencing furosemide CL and might serve as a good index for furosemide dosing in VP neonates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14735","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T06:03:59Z","timestamp":1618380239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Furosemide clearance in very preterm neonates early in life: A pilot study using scavenged samples"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7002-468X","authenticated-orcid":false,"given":"Kaoru","family":"Okazaki","sequence":"first","affiliation":[{"name":"Department of Neonatology Shikoku Medical Center for Children and Adults Kagawa Japan"},{"name":"Department of Neonatology Tokyo Metropolitan Children's Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyasu","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Laboratory of Hospital Pharmacy School of Pharmacy Nihon University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2121-1862","authenticated-orcid":false,"given":"Toru","family":"Kuboi","sequence":"additional","affiliation":[{"name":"Department of Neonatology Shikoku Medical Center for Children and Adults Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Unemoto","sequence":"additional","affiliation":[{"name":"Department of Neonatology Tokyo Metropolitan Children's Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Neonatology Tokyo Metropolitan Children's Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-737X","authenticated-orcid":false,"given":"Takashi","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"S2","article-title":"Does nephron number matter in the development of kidney disease?","volume":"16","author":"Douglas\u2010Denton RN","year":"2006","journal-title":"Ethn. 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