{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:33Z","timestamp":1753879353192,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":75,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A growing number of studies have demonstrated the efficacy of high\u2010flow nasal cannula therapy (HFNC) for treating children with acute respiratory distress. However, it remains unknown whether HFNC is effective in bedridden patients with acute respiratory distress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively reviewed the medical records of bedridden patients with acute respiratory distress who were treated with HFNC using a home ventilator in continuous positive airway pressure mode at our center between March 2014 and August 2016. We assessed heart rate, respiratory rate, oxygen saturation measured using a pulse oximeter, the partial pressure of venous carbon dioxide, or the transcutaneous partial pressure of carbon dioxide, and symptoms of respiratory distress before and after the initiation of HFNC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the 2\u2010year\u2010study period, 25 patients were treated with HFNC. The patients\u2019 mean heart rate, respiratory rate, oxygen saturation measured using a pulse oximeter, and pressure of venous carbon dioxide\/the transcutaneous partial pressure of carbon dioxide values improved significantly (<jats:italic>P<\/jats:italic> &lt; 0.05). Symptoms of respiratory distress were considerably ameliorated at 1\u20133\u2009h after the HFNC initiation, except in two patients. In these two patients, the HFNC was replaced with non\u2010invasive positive pressure ventilation. Non\u2010invasive positive pressure was also required at 16 to 168\u2009h after the initiation of HFNC in five of the 28 episodes in which the patient was initially responsive to HFNC, as the patients\u2019 respiratory symptoms gradually deteriorated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Performing HFNC with a home ventilator in continuous positive airway pressure mode is effective at treating bedridden patients with acute respiratory distress. However, it is essential that the HFNC can be switched to non\u2010invasive positive pressure if needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14756","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T18:39:51Z","timestamp":1623263991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of high\u2010flow nasal cannula therapy in bedridden patients"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-8445","authenticated-orcid":false,"given":"Kenji","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Pediatrics Shiga Medical Center for Children Moriyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Kumada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga Medical Center for Children Moriyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga Medical Center for Children Moriyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Ohno","sequence":"additional","affiliation":[{"name":"Shiga General Hospital Moriyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181d9076d"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.10.039"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-014-2275-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60249-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503326"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066609340622"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23022"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.1.75"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.017416"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.3.192"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2017.41.4.519"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073812436605"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31829e7f2f"},{"issue":"2","key":"e_1_2_7_15_1","first-page":"CD006405","article-title":"High flow nasal cannula for respiratory support in preterm infants","author":"Wilkinson D","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_16_1","first-page":"e934","article-title":"Serious air leak syndrome complicating high\u2010flow nasal cannula therapy: A report of 3 cases","volume":"131","author":"Hedge S","year":"2013","journal-title":"Pediatrics"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.14756","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T21:43:15Z","timestamp":1747431795000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.14756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/ped.14756"],"URL":"https:\/\/doi.org\/10.1111\/ped.14756","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"type":"print","value":"1328-8067"},{"type":"electronic","value":"1442-200X"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2020-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14756"}}