{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T09:28:38Z","timestamp":1788082118920,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neonatal suppurative parotitis is a rare disease, characterized mainly by unilateral parotid swelling with erythema and tenderness, and often purulent discharge from the Stensen\u2019s duct into the oral cavity. Only 44 cases were reported in the English literature between 1970 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A MEDLINE search was conducted using the terms acute, neonatal, newborn, suppurative, bacterial, purulent, parotitis, parotid swelling, and parotid abscess, limited to the English\u2010language literature starting from 2011. We reviewed all reported cases, together with two more managed cases in our hospital. We also describe the magnetic resonance imaging findings of the early stage of this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 26 new cases since 2011. The total number of patients reviewed was 72, including our patients. The infection was unilateral in 83% of patients, and 67% of the affected patients were males. The serum amylase levels were generally not elevated despite marked parotid swelling. Of the causative agents of this disease, 65% were <jats:italic>Staphylococcus aureus<\/jats:italic>, of which 19% were methicillin\u2010resistant <jats:italic>S.\u2009aureus<\/jats:italic>. As the rate of cesarean section was high in patients with this disease, it was considered a risk factor. The diffusion\u2010weighted magnetic resonance images showed multiple punctate hyperintensity regions with reduced apparent diffusion coefficient, suggesting microabscess formation in the affected gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acute suppurative parotitis should be considered in cases of swelling and tenderness in the parotid gland during the neonatal period. Multiple punctate hyperintensities in the parotid gland on the diffusion\u2010weighted images may indicate a retrograde bacterial infection from the Stensen\u2019s duct.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14762","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T01:27:48Z","timestamp":1620350868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neonatal suppurative parotitis: Case reports and literature review"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0421-2740","authenticated-orcid":false,"given":"Toshihiko","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Pediatrics NTT East Sapporo Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NTT East Sapporo Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NTT East Sapporo Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NTT East Sapporo Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NTT East Sapporo Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NTT East Sapporo Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nodoka","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NTT East Sapporo Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Fuse","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NTT East Sapporo Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000105181.74169.16"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2012.03738.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.04.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.882598"},{"key":"e_1_2_7_6_1","first-page":"631","article-title":"Parotid abscess in a late premature infant: A case report","volume":"67","author":"Zurina Z","year":"2012","journal-title":"Med. 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