{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:39Z","timestamp":1787016039062,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgroud<\/jats:title>\n                    <jats:p>Pneumonia is one of the leading causes of death in children under 5\u2009years old. Viruses have historically been the most common cause of community\u2010acquired pneumonia in children. Co\u2010infections in severe pneumonia are more concern by clinicians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>It was a perspective and descriptive study. Real\u2010time polymerase chain reaction (RT\u2010PCR) is a modern test that was used to detect many new pathogens, including microbiological co\u2010infections. RT\u2010PCR technique was used in this study to investigate the causes of severe pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Through the analysis of nasopharyngeal aspiration samples from 95 children with severe community\u2010acquired pneumonia, the positive RT\u2010PCR rate was 90.5%. Viral\u2010bacterial co\u2010infection accounted for the highest proportion (43.1%), followed by bacterial co\u2010infection (33.7%), viral infection (7.4%), bacterial infection (6.3%) and the remaining 9.5% was unknown. In the co\u2010infections groups, the five main bacteria species detected by PCR were\n                      <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      ,\n                      <jats:italic>Haemophilus influenzae<\/jats:italic>\n                      , MRSA,\n                      <jats:italic>Moraxella catarrhalis<\/jats:italic>\n                      and\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Antibiotic treatment should focus on detected microbes in cases of severe pneumonia for having a good result.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.14853","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T04:12:37Z","timestamp":1634789557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Study on the co\u2010infection of children with severe community\u2010acquired pneumonia"],"prefix":"10.1111","volume":"64","author":[{"given":"Khai","family":"Tran Quang","sequence":"first","affiliation":[{"name":"Can Tho University of Medicine and Pharmacy Can Tho Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung","family":"Tran Do","sequence":"additional","affiliation":[{"name":"Can Tho University of Medicine and Pharmacy Can Tho Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van","family":"Pham Hung","sequence":"additional","affiliation":[{"name":"Laboratory of Nam Khoa Biotek Company International Research of Gene and Immunology Institute Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung","family":"Nguyen Vu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Hanoi Medical University Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bach","family":"Tran Xuan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Hanoi Medical University Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Larsson","sequence":"additional","affiliation":[{"name":"Global Public Health Department Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5926-9544","authenticated-orcid":false,"given":"Sy","family":"Duong\u2010Quy","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Lam Dong Medical College Dalat Vietnam"},{"name":"Division of Immuno\u2010Allergology Penn State Medical College Hershey Medical Center Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy","family":"Nguyen\u2010Thi\u2010Dieu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Hanoi Medical University Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30408-X"},{"key":"e_1_2_11_3_1","first-page":"1597","volume-title":"Kendig and Chernick\u2019s Disorders of the Respiratory Tract in Children","author":"Marcelo CS","year":"2018"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020447"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30037-1"},{"key":"e_1_2_11_6_1","first-page":"e42","article-title":"Practical guidance for clinical microbiology laboratories: viruses causing acute respiratory tract infections","volume":"32","author":"Charlton CL","year":"2019","journal-title":"Clin. 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