{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:32:38Z","timestamp":1793460758890,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The coronavirus disease 2019 (COVID\u201019) and pediatric multisystem inflammatory syndrome (PIMS) are a major public health issue affecting many people worldwide. Although there are new studies in children, little is known about these two new conditions. The aim of this study was to evaluate and compare the clinical and laboratory features of children with COVID\u201019 and PIMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, single\u2010center study of pediatric COVID\u201019 and PIMS at a tertiary care hospital in Turkey between November 2020 and March 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 115 patients with COVID\u201019 and PIMS were examined during the study period. The median age was 60 (range, 1\u2013215) months and 64% of the patients were male. The most common clinical symptoms were fever (70%) and cough (43%). Conjunctivitis and skin rash were not seen in PIMS patients. Of all patients, 64% had a history of close contact in household. Lymphopenia was present in 34\/115 (30%) patients. Acute phase reactants were significantly higher in PIMS patients. Abnormal chest computed tomography scan findings were detected in 68% of the patients, while 36% had abnormal echocardiographic findings. In multivariate analysis, longer duration of fever, diarrhea, lower thrombocyte and higher neutrophil count were significantly associated with diagnosis of PIMS. The treatment included antibiotics, favipiravir, intravenous immunoglobulin, corticosteroids, interleukin\u20101 blockade.\u2009and supportive therapy. Seven patients (6%) required intensive care support. All patients were discharged without any complications, except one who died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Longer duration of fever, diarrhea, lower thrombocyte, and higher neutrophil count can warn clinicians for diagnosis of PIMS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.14884","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T08:01:49Z","timestamp":1643011309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of clinical and laboratory features in coronavirus disease 2019 and pediatric multisystem inflammatory syndrome patients"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6383-0568","authenticated-orcid":false,"given":"Nurhayat","family":"Yakut","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Infectious Diseases Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrullah","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut","family":"Algul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Armut","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burhaneddin","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Karagoz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahraman","family":"Yakut","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arda","family":"Kilinc","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Cansaran","family":"Tanidir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"153","article-title":"Epidemiological characteristics and prevention and control measures of corona virus disease 2019 in children","volume":"20","author":"Jiatong S","year":"2020","journal-title":"J. Trop. Med."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000044"},{"key":"e_1_2_9_4_1","unstructured":"Johns Hopkins Coronavirus Resource Center.Coronavirus COVID\u201019 global cases by the center for systems science and engineering (CSSE) at Johns Hopkins University. [Cited 7 April 7 2020.] Available fromhttps:\/\/coronavirus.jhu.edu\/map.html"},{"key":"e_1_2_9_5_1","unstructured":"World Health Organization.Coronavirus disease (COVID\u201019) situation reports [Internet]. [Cited 21 June 2021.] Available fromhttps:\/\/www.who.int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019\/situation\u2010reports"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30154-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31094-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10369"},{"key":"e_1_2_9_9_1","unstructured":"World Health Organization.Multisystem inflammatory syndrome in children and adolescents temporally related to COVID\u201019 [Internet]. [Cited 11 January 2021.] Available from https:\/\/www.who.int\/news\u2010room\/commentaries\/detail\/multisystem\u2010inflammatorysyndrome\u2010in\u2010children\u2010and\u2010adolescents\u2010with\u2010covid\u201019"},{"key":"e_1_2_9_10_1","unstructured":"Centers for Disease Control and Prevention.Multisystem inflammatory syndrome in children (MIS\u2010C) associated with coronavirus disease 2019 (COVID\u201019) [Internet]. [Cited 11 January 2021.] Available fromhttps:\/\/emergency.cdc.gov\/han\/2020\/han00432.asp"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-020-00362-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2648"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-020-03322-y"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25807"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2007617"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-0702"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2005073"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2020.03.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.18.2000600"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021756"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19163"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.1948"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24991"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa556"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.14549"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2020.02.011"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30232-2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-020-1819-5"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piaa069"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141113"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.26.20044826"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095026882000196X"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002888"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.2091"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI140970"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26398"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30145-0"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15270"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.14884","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:26:50Z","timestamp":1793460410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.14884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/ped.14884"],"URL":"https:\/\/doi.org\/10.1111\/ped.14884","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14884"}}