{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:57:26Z","timestamp":1765486646571,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"vor","delay-in-days":70,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072015"],"award-info":[{"award-number":["82072015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hand\u2010foot\u2010mouth disease (HFMD) is a significant public health concern, especially in Asia\u2010Pacific countries. Its diagnosis mainly depends on clinical symptoms. It is easy to miss the source of infection and best treatment period. This research aims to provide a tool for its early clinical diagnosis and for predicting the possibility of complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The serum samples of 39 HFMD children and 36 healthy children were collected for clinical testing and <jats:sup>1<\/jats:sup>H\u2010NMR spectroscopy. Metabolomic analyses were performed to obtain the metabolic differences between the HFMD and healthy children and to speculate on the pathogenesis of HFMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine children were divided into severe cases and mild cases. Severe cases demonstrated more obvious inflammatory responses, but no metabolic difference was observed between the severe and mild cases. The metabolic differences between HFMD and healthy children were noticeable. Ten differential metabolites were screened out as the potential biomarkers for HFMD, and seven disturbed metabolic pathways responsible for HFMD were affected by inflammation, impaired intestinal absorptive function, and immune response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results will provide a complementary tool for the early diagnosis of HFMD and potential ideas for later treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14927","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T16:41:21Z","timestamp":1626540081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Metabolomic characteristics of hand\u2010foot\u2010mouth disease facilitate discovery and diagnosis of pathogeny"],"prefix":"10.1111","volume":"64","author":[{"given":"Hongwei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Xiamen University Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanhuan","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8899-2750","authenticated-orcid":false,"given":"Jianghua","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Xiamen University Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiping","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Xiamen University Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70342-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-94"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/v7122947"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01231-13"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178259"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12468"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000246"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants8120560"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15038744"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2015.02.024"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.08.016"},{"key":"e_1_2_8_13_1","first-page":"5057","article-title":"Serum level of peptide LL\u201037 in patients with hand\u2010foot\u2010mouth disease caused by enterovirus 71 infection","volume":"11","author":"Yang H","year":"2018","journal-title":"Int. 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