{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:43:24Z","timestamp":1753879404759,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":97,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infectious diseases can result in a catabolic state and possibly trigger an acute metabolic decompensation in inborn errors of metabolism (IEM), which could be life threatening. Studies regarding the course of severe acute respiratory syndrome coronavirus 2 infections in patients with IEM are generally limited to case reports. Here, we aimed to evaluate the clinical findings of coronavirus disease 2019 (COVID\u201019) and describe the impact of severe acute respiratory syndrome coronavirus 2 infections on metabolic outcomes in IEM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who were diagnosed with different types of IEM and developed microbiologically confirmed COVID\u201019 infection were included. Clinical findings and laboratory results were recorded retrospectively in terms of both IEM and COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven patients with diagnosis of intoxication type metabolic disorders, five patients with energy metabolism disorders, and six patients with complex molecular disorders were enrolled. The most frequent clinical finding was fever (52.1%) followed by fatigue\/myalgia (47.8%). None of the patients was younger than 1\u2009year. None of the patients presented severe or critical disease. In terms of metabolic decompensation, two patients diagnosed with propionic acidemia, one patient with methylmalonic acidemia and one patient with 3\u2010hydroxy\u20103\u2010methylglutaryl\u2010CoA lyase deficiency presented clinical and biochemical findings of an acute metabolic attack.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on our results, IEM are not found to be an additional risk factor for severe COVID\u201019 infection. However, patients with intoxication type and energy metabolism disorders should be considered as a vulnerable population for COVID\u201019 and have a major risk of developing acute metabolic decompensation that can lead to life\u2010threatening complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14938","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T18:52:26Z","timestamp":1627671146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inborn errors of metabolism and coronavirus disease 2019: Evaluation of the metabolic outcome"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7159-4008","authenticated-orcid":false,"given":"Tanyel","family":"Zubarioglu","sequence":"first","affiliation":[{"name":"Division of Nutrition and Metabolism Department of Pediatrics Cerrahpasa Medical Faculty Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duhan","family":"Hopurcuoglu","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Department of Pediatrics Cerrahpasa Medical Faculty Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saffa","family":"Ahmadzada","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Department of Pediatrics Cerrahpasa Medical Faculty Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6zde","family":"Uzunyayla\u2010Inci","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Department of Pediatrics Cerrahpasa Medical Faculty Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Serif","family":"Cansever","sequence":"additional","affiliation":[{"name":"Division of Medical Laboratory Techniques Department of Medical Documentation and Techniques The Vocational School of Health Services Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5170-5594","authenticated-orcid":false,"given":"Ertugrul","family":"Kiykim","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Department of Pediatrics Cerrahpasa Medical Faculty Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7256-0750","authenticated-orcid":false,"given":"Cigdem","family":"Aktuglu\u2010Zeybek","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Department of Pediatrics Cerrahpasa Medical Faculty Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-49771-5_1"},{"volume-title":"Homepage on the internet","author":"World Health Organization","key":"e_1_2_7_3_1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-0702"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.14744\/TurkPediatriArs.2020.20270"},{"key":"e_1_2_7_6_1","first-page":"341","article-title":"Characteristics and management of children with COVID\u201019 in Turkey","volume":"37","author":"Cura\u2010Yayla BC","year":"2020","journal-title":"Balkan Med. 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