{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:28:59Z","timestamp":1793489339886,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of type 1 diabetes mellitus (T1DM) in children and adolescents continues to increase worldwide. The reason for this is unclear. In addition to the role of genetics, bisphenol A (BPA) has been investigated as a possible causal factor for T1DM. This study aimed to determine the correlation between urinary BPA levels and T1DM in Thai children and adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted in T1DM patients who were followed at the endocrinology clinic at King Chulalongkorn Memorial Hospital from December 2018 to December 2019 and age\u2010matched healthy controls. Urinary BPA levels were analyzed by high\u2010performance liquid chromatography and adjusted by urine creatinine. Anthropometric data were measured in all participants and clinical data were collected for the T1DM patients. All participants completed a questionnaire regarding possible BPA exposures. Multivariate logistic regression analysis was used to estimate the adjusted odds ratio for T1DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010five T1DM patients and 113 age\u2010matched controls were included in the study. The mean age for T1DM and control groups were 14.8\u2009\u00b1\u20095.7 and 14.4\u2009\u00b1\u20096.2\u2009years, respectively. The T1DM group had a significantly higher median (interquartile range) level of adjusted urinary BPA compared to the control (31.50 [7.87, 69.45] vs 10.1 [0, 54.01] \u03bcg\/g creatinine,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). Urinary BPA of 17\u2009\u03bcg\/g creatinine or more was significantly associated with TIDM, with adjusted odds ratio (95% Confident interval, CI) of 2.38 (1.27, 4.44),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher urinary BPA level is one of the possible risk factors for T1DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.14944","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T11:32:23Z","timestamp":1627990343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Increased bisphenol A levels in Thai children and adolescents with type 1 diabetes mellitus"],"prefix":"10.1111","volume":"64","author":[{"given":"Naruporn","family":"Tosirisuk","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Pediatrics Faculty of Medicine King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natee","family":"Sakorn","sequence":"additional","affiliation":[{"name":"School of Pharmacy Walailak University Nakhon Si Thammarat Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chutima","family":"Jantarat","sequence":"additional","affiliation":[{"name":"School of Pharmacy Walailak University Nakhon Si Thammarat Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wichit","family":"Nosoongnoen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Pharmacy Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suphab","family":"Aroonpakmongkol","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Pediatrics Faculty of Medicine King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3173-4133","authenticated-orcid":false,"given":"Vichit","family":"Supornsilchai","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Pediatrics Faculty of Medicine King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"17","article-title":"Bisphenol A: product profile","volume":"78","author":"Burridge E","year":"2003","journal-title":"Eur. 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