{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T21:30:53Z","timestamp":1775338253570,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammation and endothelial dysfunction are the suggested underlying mechanisms in migraine. Pentraxins, C\u2010reactive protein, erythrocyte sedimentation rate, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio are good indicators of inflammation. Alterations in insulin levels and insulin sensitivity may trigger endothelial dysfunction. This study evaluates the association between migraine and serum biomarkers of inflammation and endothelial dysfunction in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children with migraine and healthy subjects were recruited. Serum samples were obtained in an attack\u2010free period. We collected data on serum levels of complete blood cell count, C\u2010reactive protein, erythrocyte sedimentation rate, pentraxin\u20103, and data from biochemical investigations. We compared these with clinical data such as age, sex, disease duration, attack frequency, attack duration, analgesic use, family history, and Pediatric Migraine Disability Assessment Questionnaire scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We assessed samples from 32 children (11 boys, 21 girls) with migraine and 19 healthy controls (8 boys, 11 girls). We found significantly higher pentraxin\u20103, insulin, and insulin resistance in patients with migraine (<jats:italic>P<\/jats:italic>\u2009=\u20090.001, <jats:italic>P<\/jats:italic>\u2009=\u20090.032, and <jats:italic>P<\/jats:italic>\u2009=\u20090.008, respectively). A positive directional correlation is found between pentraxin\u20103 and Pediatric Migraine Disability Assessment Questionnaire scores. The best cut\u2010off values for pentraxin\u20103 is determined between 12.75\u2009pg\/mL to 15\u2009pg\/mL in migraineurs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion increased pentraxin\u20103 levels support the suggestions that inflammation plays a role in pediatric migraine. The vascular endothelial dysfunction is observed by a rise in insulin and insulin resistance levels. Our findings support the idea that ongoing inflammation and vascular endothelial dysfunction between attacks may play a role in migraine pathogenesis in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14946","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T18:42:20Z","timestamp":1628275340000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inflammation and endothelial dysfunction in pediatric migraine patients"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8270-3249","authenticated-orcid":false,"given":"\u0130pek","family":"Polat","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology Dokuz Eyl\u00fcl University School of Medicine  Izmir Turkey"},{"name":"Izmir International Biomedicine and Genom Institute Dokuz Eyl\u00fcl University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-8822","authenticated-orcid":false,"given":"Pakize","family":"Karao\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Dokuz Eyl\u00fcl University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali R\u0131za","family":"\u015ei\u015fman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Dokuz Eyl\u00fcl University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulu\u00e7","family":"Yi\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Dokuz Eyl\u00fcl University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semra","family":"H\u0131z Kurul","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Dokuz Eyl\u00fcl University School of Medicine  Izmir Turkey"},{"name":"Izmir International Biomedicine and Genom Institute Dokuz Eyl\u00fcl University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8434-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0202-136"},{"key":"e_1_2_8_4_1","first-page":"16","article-title":"Deciphering migraine","volume":"119","author":"Takano T","year":"2009","journal-title":"J. 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