{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:37Z","timestamp":1753879297186,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":123,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive candidiasis (IC) is a leading cause of morbidity and mortality in preterm infants. The objective of this study was to determine the prevalence of IC infection in newborns in the neonatal intensive care unit (NICU) of a tertiary hospital in Japan, and to identify specific predisposing factors for IC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected data on demographics, clinical characteristics, and outcomes of infants with IC, who were discharged from a tertiary NICU in Japan between January 2009 and December 2020. We compared predisposing factors associated with the occurrence of early\u2010onset IC (EOIC &lt; 72\u2009h) and late\u2010onset IC (LOIC \u2265\u00a072\u2009h) with those of early\u2010onset and late\u2010onset bacterial sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between January 2009 and December 2020, 3,549 infants were admitted to the NICU, including 344 extremely\u2010low birthweight (ELBW) infants. Eleven infants (including nine ELBW infants) had IC (incidence 0.31%), and the mortality rate of IC was 0%. Four (36%) infants had EOIC and seven (64%) had LOIC. All those with EOIC presented with skin lesions and 86% with LOIC had thrombocytopenia. Maternal vaginal <jats:italic>Candida<\/jats:italic> colonization was a more specific predisposing factor for EOIC, while gestational age &lt;26\u2009weeks, broad\u2010spectrum antibiotic use, prior bacterial infection, prior gastrointestinal (GI) surgery, and GI diseases were more specific predisposing factors for LOIC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings suggest that maternal vaginal <jats:italic>Candida<\/jats:italic> colonization and skin lesions in ELBW infants may contribute to early recognition of EOIC. LOIC should be suspected if ELBW infants with several predisposing factors of LOIC have thrombocytopenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14949","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T08:23:06Z","timestamp":1628842986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Invasive candidiasis in a neonatal intensive care unit in Fukuoka"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0546-0770","authenticated-orcid":false,"given":"Eiji","family":"Ohta","sequence":"first","affiliation":[{"name":"Division of Neonatology Center for Maternal, Fetal and Neonatal Medicine Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Setoue","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal, Fetal and Neonatal Medicine Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsurou","family":"Kodera","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal, Fetal and Neonatal Medicine Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Onda","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal, Fetal and Neonatal Medicine Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Kawano","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal, Fetal and Neonatal Medicine Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikazu","family":"Niimi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal, Fetal and Neonatal Medicine Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Kakura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Morii","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal, Fetal and Neonatal Medicine Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chizuru","family":"Hashiguchi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal, Fetal and Neonatal Medicine Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal, Fetal and Neonatal Medicine Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2005.04.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200004000-00011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0671"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.2.438"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.10.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02074-0"},{"key":"e_1_2_8_11_1","first-page":"CD003478","article-title":"Prophylactic oral\/topical non\u2010absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants","volume":"2015","author":"Austin N","year":"2015","journal-title":"Cochrane. 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