{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:29:10Z","timestamp":1787822950368,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Respiratory syncytial virus (RSV) is a major cause of hospitalization for bronchiolitis and pneumonia in infancy. In Japan, limited data are publicly available on RSV epidemiology and clinical characteristics among infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study described RSV incidence, seasonality, patient characteristics, resource use, and clinical outcomes among Japanese children &lt;2\u2009years from January 2017 through December 2018. The RSV cases were identified using the Japanese Medical Data Center database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the database, 9,711 and 8,509 RSV patients &lt;2\u2009years were identified in 2017 and 2018, respectively. Of these, 25% required hospitalization. Ninety percent of hospitalized patients did not have a known RSV risk factor. Nineteen percent of hospitalized patients experienced dehydration, and 12% had acute respiratory failure. Hospitalization lasted 1\u2009week on average and 7% required some type of mechanical ventilation. The peak of hospitalizations occurred at 2\u2009months. The incidence of RSV hospitalization in children &lt;2\u2009years was 23.2 per 1,000 person\u2010years, which increased to 35.4 per 1,000 for infants &lt;6\u2009months. This age group accounted for 40% of all RSV\u2010associated hospitalizations among children &lt;2\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Roughly one\u2010fourth of all RSV patients &lt;2\u2009years were hospitalized. Ninety percent of these did not have an underlying risk condition. This underscores that RSV can cause serious disease among all young children. Three to four out of every 100 Japanese children &lt;6\u2009months were hospitalized for RSV, and this age group accounted for ~40% of all RSV\u2010associated hospitalizations. Novel and broad\u2010based RSV prevention strategies, especially those targeting young infants, are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.14957","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T17:00:18Z","timestamp":1628874018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Epidemiology of respiratory syncytial virus in Japan: A nationwide claims database analysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3587-6611","authenticated-orcid":false,"given":"Yasuhiro","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Vaccine Medical Affairs Pfizer Japan Inc Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanae","family":"Togo","sequence":"additional","affiliation":[{"name":"Health &amp; Value Pfizer Japan Inc Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen","family":"Agosti","sequence":"additional","affiliation":[{"name":"Viral Vaccines Pfizer Inc Collegeville PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Pipeline Vaccines Pfizer Inc Collegeville PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200207000-00005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.430"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw756"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-730OC"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1666"},{"key":"e_1_2_8_8_1","first-page":"207","volume-title":"Respiratory syncytial virus infection, January 2014\u2010September 2018","author":"Infectious Agents Surveillance Report (IASR)","year":"2018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.1913P3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.08.015"},{"key":"e_1_2_8_11_1","volume-title":"JMDC Database","author":"Japan Medical Data Company","year":"2020"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.14410"},{"key":"e_1_2_8_13_1","unstructured":"AbbVie.Package Insert of Palivizumab in Japan Revised March 2019 (6thedn.) 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