{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:33:31Z","timestamp":1793363611446,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":124,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients whose parents had a history of Kawasaki disease (KD) often show a poor response to intravenous immunoglobulin (IVIG). There are very few reports describing the clinical characteristics and no reports on changes in C\u2010reactive protein (CRP) level after IVIG administration in such cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single\u2010center cohort study including 950 patients hospitalized for KD and treated with IVIG was conducted. The patients were divided into two groups: patients whose parents had a history of KD (PHK) (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200916) and patients whose parents had no history of KD (NPHK) (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009934). The clinical characteristics and responsiveness to IVIG were compared between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The PHK group had higher CRP levels before administering IVIG than the NPHK group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0010). CRP levels after IVIG administration were higher in the PHK group than in the NPHK group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0094). The percentage of patients who received a second administration of IVIG on day 2 after the initial IVIG therapy was higher in the PHK group than in the NPHK group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0016). The percentage of patients who required plasma exchange therapy in the PHK group was significantly higher than that in the NPHK group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients in the PHK group had severe KD before IVIG administration, and these patients showed poor responsiveness to IVIG therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.14963","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T15:53:40Z","timestamp":1629388420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Poor response to intravenous immunoglobulin in patients with a parental history of Kawasaki disease"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9767-6354","authenticated-orcid":false,"given":"Mitsuji","family":"Iwasa","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nagoya Nishi Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Inukai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nagoya Daini Red Cross Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.05.034"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00602.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.12.1166"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200x.2005.02033.x"},{"key":"e_1_2_10_6_1","volume-title":"Report of subcommittee on standardization of diagnostic criteria and reporting of coronary artery lesions in Kawasaki disease","author":"Research Committee on Kawasaki Disease","year":"1984"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2011.03487.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2006.02221.x"},{"key":"e_1_2_10_10_1","unstructured":"Results from the nationwide survey in 2003\u20102004 [homepage on the internet] [Cited 2016.] Available fromhttp:\/\/www.jichi.ac.jp\/dph\/kawasakibyou\/report20100714\/mcls18report.pdf(in Japanese). ( on Aug. 29th 2021)."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE2008001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20090180"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20110126"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20140089"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13544"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13809"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2010.03267.x"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.14963","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.14963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:57:34Z","timestamp":1793361454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.14963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/ped.14963"],"URL":"https:\/\/doi.org\/10.1111\/ped.14963","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14963"}}