{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:28:57Z","timestamp":1793507337536,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":108,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We investigated the pathogenic, clinical, and laboratory characteristics of children diagnosed with septic arthritis (SA) during the past 24\u2009years and identified the risk factors for SA\u2010related sequelae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the records of patients admitted to Fukuoka University Hospital from 1997 to 2020. Causative pathogens were compared between the first (1997\u20132008) and second (2009\u20132020) periods. We also compared the clinical and laboratory characteristics in patients with known or unknown pathogens, and in patients with or without sequelae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 37 patients with SA were identified, including 28 patients (76%) in the first period and nine patients (24%) in the second period. Sixteen of 37 patients (43%) were younger than 2\u2009years, including two neonates. Pathogens were identified in 25 (68%) of 37 patients. Patients with known pathogens had a significantly higher C\u2010reactive protein level on admission than those with unknown pathogens (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). The predominant pathogen was\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (38%, 14\/37). Although\n                      <jats:italic>S.\u2009aureus<\/jats:italic>\n                      and\n                      <jats:italic>Hemophilus influenzae<\/jats:italic>\n                      type b (Hib) were predominant pathogens in the first period, Hib was not found in the second period. Six (16%) of 37 patients with SA experienced sequelae. Moreover, the risk factors for the development of sequelae were significantly associated with infection at age &lt;1\u2009month and delayed surgical treatment (&gt;4\u2009days).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of SA had decreased dramatically in the second period, and Hib was no longer the predominant pathogen. Earlier surgical drainage should be performed in neonates with SA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.14993","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T01:25:10Z","timestamp":1631755510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Septic arthritis in childhood: A 24\u2010year review"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0546-0770","authenticated-orcid":false,"given":"Eiji","family":"Ohta","sequence":"first","affiliation":[{"name":"Division of Neonatology Center for Maternal Fetal and Neonatal Medicine Fukuoka University Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Setoue","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal Fetal and Neonatal Medicine Fukuoka University Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsurou","family":"Kodera","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal Fetal and Neonatal Medicine Fukuoka University Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Onda","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal Fetal and Neonatal Medicine Fukuoka University Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Kawano","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal Fetal and Neonatal Medicine Fukuoka University Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"Niimi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Center for Maternal Fetal and Neonatal Medicine Fukuoka University Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Kakura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-6050","authenticated-orcid":false,"given":"Shinichiro","family":"Nagamitsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"41","article-title":"Septic arthritis in children: relationship of causative pathogens, complications, and outcome","volume":"36","author":"Wang CL","year":"2003","journal-title":"J. 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