{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:37:15Z","timestamp":1762522635562,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Candida<\/jats:italic> urinary tract infections (UTIs) are common nosocomial infections among critically ill patients hospitalized in pediatric intensive care Units (PICU). We aimed to report outcomes of critically ill pediatric patients who received micafungin for hospital acquired <jats:italic>Candida<\/jats:italic> UTIs. We analyzed treatment success rates and success rates among different <jats:italic>Candida<\/jats:italic> species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included patients who received micafungin for <jats:italic>Candida<\/jats:italic> UTI as first choice in our PICU between January 2017 and July 2018. Data, including demographic and clinical features, were retrospectively collected from medical files of the patients. Treatment efficacy was defined as resolution of clinical symptoms and a negative culture for <jats:italic>Candida<\/jats:italic> at day 14 after initiation of micafungin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four pediatric patients (median age 5.72\u2009years, range, 2\u2009months\u201316\u2009years) were included in the present study. Fourteen (58.3%) patients had urinary catheters at the time of <jats:italic>Candida<\/jats:italic> isolation. Resolution of symptoms and a negative culture at day 3 of micafungin treatment were achieved in 17 (70.8%) and 14 (58.3%) patients, respectively. Moreover, 19 (79.2%) patients had a normal urine analysis and negative culture 14\u2009days after initiation of micafungin treatment. Treatment responses did not statistically differ between <jats:italic>Candida<\/jats:italic> species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Micafungin is safe and efficacious in critically ill pediatric patients with <jats:italic>Candida<\/jats:italic> UTIs. Its efficacy in our pediatric population was as comparable to that observed in adult studies, therefore, it should be considered as an effective therapeutic option in <jats:italic>Candida<\/jats:italic> UTIs of critically ill pediatric patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15033","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T20:45:53Z","timestamp":1634849153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of <i>Candida<\/i> urinary tract infections with micafungin in children"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6675-3150","authenticated-orcid":false,"given":"Faruk","family":"Ekinci","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care \u00c7ukurova University Faculty of Medicine Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-5108","authenticated-orcid":false,"given":"Dincer","family":"Yildizdas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care \u00c7ukurova University Faculty of Medicine Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7590-650X","authenticated-orcid":false,"given":"Ozden Ozgur","family":"Horoz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care \u00c7ukurova University Faculty of Medicine Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-7645","authenticated-orcid":false,"given":"Ozlem","family":"Ozgur Gundeslioglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases \u00c7ukurova University Faculty of Medicine Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4809-2883","authenticated-orcid":false,"given":"Derya","family":"Alabaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases \u00c7ukurova University Faculty of Medicine Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/501755"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199905000-00020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/313583"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmq104"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir109"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2016.03.056"},{"key":"e_1_2_7_8_1","first-page":"318","article-title":"Evaluation of risk factors in patients with candiduria","volume":"45","author":"Nayman Alpat S","year":"2011","journal-title":"Mikrobiyol. 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