{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:48Z","timestamp":1753879368239,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":171,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2019\u2010ER7103\u201002#"],"award-info":[{"award-number":["2019\u2010ER7103\u201002#"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neonatal bacterial meningitis (BM) has an incidence of 0.2\u20130.4 per 1,000 births and a mortality rate of 20\u201325%. Data from the Korean Neonatal Network (KNN) were evaluated to study the incidence, mortality, and risk factors associated with BM in very\u2010low\u2010birthweight (VLBW; &lt;1,500\u2009g) infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed KNN data from 2013\u20132016 collected from 70 neonatal units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of BM in VLBW infants was 40 out of 8,263 (0.5%). The 40 infants with BM had a mean gestational age of 27.1 \u00b1 2.0\u2009weeks and a mean birthweight of 1,036.8 \u00b1 220.0\u2009g. Mean age at diagnosis was 51.5 \u00b1 38.3\u2009days (range, 1\u2013171). Infants with BM were divided into two groups: Group 1 (onset age \u2264 28\u2009days) and Group 2 (onset age &gt; 28\u2009days). Coagulase\u2010negative <jats:italic>Staphylococcus<\/jats:italic> (CONS) was the most common pathogen underlying meningitis in 11 of 40 cases (28%). BM co\u2010occurred with bacteremia in 14 of 40) of cases (35%); bacteremia was significantly more common in Group 1 than Group 2 (<jats:italic>P<\/jats:italic> &lt; 0.05). Seizure and intraventricular hemorrhage (\u2265grade 3) were significantly more prevalent in Group 2 than Group 1 (<jats:italic>P<\/jats:italic> &lt; 0.05). The mortality rate of infants with BM was 4 out of 40 (10%), which was significantly lower than that of VLBW infants without BM (1,152\/8,223, [14%]; <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of BM in VLBW infants was high, but the mortality rate was low. CONS was the most common pathogen of BM in VLBW infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15057","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T09:18:22Z","timestamp":1636967902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Short information: Bacterial meningitis in very low birthweight infants in Korea from 2013\u20132016"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7945-0511","authenticated-orcid":false,"given":"Yu Jin","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kosin University Gospel Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60108-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0707601"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.066134"},{"key":"e_1_2_7_5_1","first-page":"938","article-title":"Clinical outcome and prognosis of neonatal bacterial meningitis","volume":"20","author":"Ben HH","year":"2013","journal-title":"Arch. 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