{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:54:37Z","timestamp":1777560877471,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":125,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the efficacy of sivelestat sodium hydrate (SSH) as a treatment for Kawasaki disease, and its pharmacological action sites, in mice with <jats:italic>Candida albicans<\/jats:italic> water\u2010soluble fraction\u2010induced vasculitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sivelestat sodium hydrate was administered intraperitoneally to <jats:italic>Candida albicans<\/jats:italic> water\u2010soluble fraction\u2010induced vasculitis model mice to assess its efficacy in preventing the development of coronary artery lesions based on the degree of inflammatory cell infiltration in the aortic root and coronary arteries (vasculitis score). The pharmacological sites of action were investigated based on changes in neutrophil elastase (NE) and intercellular adhesion molecule 1 (ICAM\u20101) positive areas, ICAM\u20101 and tumor necrosis factor\u2010\u03b1 mRNA expression levels in the upper heart, and the proportion of monocytes in the peripheral blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The vasculitis score decreased below the lower limit of the 95% confidence interval of untreated mice in 69% of the SSH\u2010treated mice. The NE\u2010 and ICAM\u20101\u2010positive regions, and the mRNA expression of ICAM\u20101 and tumor necrosis factor\u2010\u03b1 were lower in the SSH\u2010treated mice than in the untreated mice. The proportion of monocytes in the peripheral blood was higher in the SSH\u2010treated mice than in the untreated mice, whereas monocyte migration to inflammation areas was suppressed in the SSH\u2010treated mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results showed that SSH might prevent the development of coronary artery lesions and ameliorate disease activity. In addition to its NE\u2010inhibitory effect, SSH sites of action may also include monocytes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15153","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T01:09:11Z","timestamp":1643418551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sivelestat's effect on <i>Candida albicans<\/i> water\u2010soluble fraction\u2010induced vasculitis"],"prefix":"10.1111","volume":"64","author":[{"given":"Yuya","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Banno\u2010Terada","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"},{"name":"Department of Pharmacy Aizenbashi Hospital Osaka City Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toui","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naofumi","family":"Takagaki","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoi","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arisa","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaka","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Mamiya","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Nagi\u2010Miura","sequence":"additional","affiliation":[{"name":"Laboratory for Immunopharmacology of Microbial Products School of Pharmacy Tokyo University of Pharmacy and Life Sciences Hachioji Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohito","family":"Ohno","sequence":"additional","affiliation":[{"name":"Laboratory for Immunopharmacology of Microbial Products School of Pharmacy Tokyo University of Pharmacy and Life Sciences Hachioji Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2320-7958","authenticated-orcid":false,"given":"Takeyuki","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Hirakata Osaka Japan"},{"name":"Research Institute for Production Development Sakyo\u2010ku Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.61.1.100"},{"key":"e_1_2_7_3_1","volume-title":"Results of the 24th Nationwide Survey of Kawasaki disease Survey","author":"Nationwide Survey of Kawasaki Disease Working Group","year":"2017"},{"key":"e_1_2_7_4_1","first-page":"1617","article-title":"Immunoglobulin therapy","volume":"72","author":"Ogata S","year":"2014","journal-title":"Jpn. 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