{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:45:06Z","timestamp":1762508706654,"version":"3.41.2"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":311,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Knowledge of chronic kidney disease (CKD) with pubertal disorders (PD) in adolescent boys is limited as few studies have explored this disorder. This study aimed to identify the usefulness of assessing hormonal parameters in male adolescents with CKD and their correlation with PD in a 12\u2010month follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study was conducted among male adolescents with CKD (stages IV and V). Data regarding the age at puberty onset were collected from the patients\u2019 clinical records and through interview. The patients were followed up for 12\u2009months during their pubertal development. At the beginning, routine hormonal profile tests were performed to examine the patients\u2019 thyroid profile, prolactin levels, luteinizing hormone, follicle\u2010stimulating hormone, testosterone, leptin, and receptor leptin. The hormonal profiles of patients with and without PD were compared. Comparisons between the groups were performed using the Student <jats:italic>t\u2010<\/jats:italic>test and Fisher's exact tests. Logistic regression analysis was also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data of 64 patients (26\/64 with PD) were analyzed. The median age was 15\u2009years and the median time for CKD evolution was 11\u2009months. No differences between groups were noted in the general or biochemical characteristics of the patients. The hormonal parameters, prolactin levels were higher and the free leptin and free thyroxine levels were lower in patients with PD. Leptin receptor levels of &gt;0.90\u2009ng\/mL (risk ratio [RR], 8.6; <jats:italic>P<\/jats:italic>\u2009=\u20090.004) and hyperprolactinemia (RR, 21.3; <jats:italic>P<\/jats:italic>\u2009=\u20090.049) were the risk factors for PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Leptin receptor levels of &gt;0.90\u2009ng\/mL and hyperprolactinemia are associated with the development of PD in male adolescents with CKD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15183","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T08:11:54Z","timestamp":1646035914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Leptin receptor and prolactin in pubertal disorders and chronic kidney disease"],"prefix":"10.1111","volume":"64","author":[{"given":"Miguel A","family":"Villas\u00eds\u2010Keever","sequence":"first","affiliation":[{"name":"Research Unit in Analysis and Synthesis of the Evidence National Medical Center XXI Century Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie N","family":"Zurita\u2010Cruz","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad Nacional Aut\u00f3noma de Mexico Hospital Infantil de Mexico Federico G\u00f3mez  Mexico City Mexico"},{"name":"Unit of Research in Medical Nutrition National Medical Center XXI Century Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juana","family":"Serret\u2010Montoya","sequence":"additional","affiliation":[{"name":"Adolescent Medicine Service Hospital Infantil de Mexico Federico G\u00f3mez Ministry of Health (SSA)  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia del Carmen","family":"Zepeda\u2010Martinez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephology Children\u2019s Hospital National Medical Center XXI Century Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Alegria\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephology Children\u2019s Hospital National Medical Center XXI Century Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-2267","authenticated-orcid":false,"given":"Aly S","family":"Barradas\u2010Vazquez","sequence":"additional","affiliation":[{"name":"Unit of Research in Medical Nutrition National Medical Center XXI Century Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz C","family":"Hern\u00e1ndez\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephology Children\u2019s Hospital National Medical Center XXI Century Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara R","family":"Alonso\u2010Flores","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephology Children\u2019s Hospital National Medical Center XXI Century Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Manuel\u2010Apolinar","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit Centro M\u00e9dico Nacional Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Damasio\u2010Santana","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit Centro M\u00e9dico Nacional Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2005.07.009"},{"key":"e_1_2_9_3_1","first-page":"590","article-title":"Disorders of puberty: an approach to diagnosis and management","volume":"96","author":"Klein DA","year":"2017","journal-title":"Am. 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