{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:47:44Z","timestamp":1773017264694,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":290,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the standard values for gender\u2010 and age\u2010stratified serum pepsinogen (sPG) in <jats:italic>Helicobacter pylori (H.\u2009pylori)<\/jats:italic> non\u2010infected children and to determine the optimal cut\u2010off values of sPG for predicting <jats:italic>H.\u2009pylori<\/jats:italic>\u2010infected gastritis in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study for determination of sPG levels was performed in children with epigastric pain who underwent esophagogastroduodenoscopy over the past 16\u2009years. After excluding subjects diagnosed with inflammatory bowel diseases, eosinophilic gastrointestinal disorders, or immunoglobulin A vasculitis, the diagnosis of <jats:italic>H.\u2009pylori<\/jats:italic> infection was defined by positive tissue culture or concordant\u2010positive results for histology and the rapid urease test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 405 subjects were diagnosed as being <jats:italic>H.\u2009pylori<\/jats:italic>\u2010infected (79) or non\u2010infected (326). In the <jats:italic>H.\u2009pylori<\/jats:italic> non\u2010infected group, there were no significant differences in sPG levels among age groups; males had higher sPG I and sPG II levels than females. In the <jats:italic>H.\u2009pylori<\/jats:italic>\u2010infected group, sPG I and sPG II levels were significantly higher and the sPG I\/II ratio was lower than those in the non\u2010infected group. In receiver operating characteristics analyses in diagnosing <jats:italic>H.\u2009pylori<\/jats:italic> infection, the areas under the curves for sPG I, sPG II and sPG I\/II ratio were 0.896, 0.980, and 0.946, respectively. The optimal cut\u2010off value of sPG II of \u22659.0\u2009ng\/mL was considered positive for <jats:italic>H.\u2009pylori<\/jats:italic> infection (sensitivity: 92.4%, specificity: 93.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The optimal cut\u2010off value of sPG II of \u22659.0\u2009ng\/mL may be a good predictor of <jats:italic>H.\u2009pylori<\/jats:italic>\u2010infected gastritis in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15247","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T07:39:30Z","timestamp":1653032370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum pepsinogen cut\u2010off values in <i>Helicobacter pylori<\/i>\u2010infected children"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4042-3353","authenticated-orcid":false,"given":"Shin\u2010ichi","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Pediatrics Sapporo Kosei General Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsuko","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Kosei General Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Kosei General Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nariaki","family":"Toita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Kosei General Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sapporo Kosei General Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182227e90"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001408"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001594"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(70)80059-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1957.37.4.475"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.1.13"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(82)90176-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02774209"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-006-0397-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20180119"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283086757"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.5.26.137"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.5.2246-2250.2005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31817d756e"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12217"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0941"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00732.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000103886"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.12.014"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1381-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200302000-00011"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.893467"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb00913.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.06.022"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083999"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408369309084670"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01297088"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018873717985"},{"key":"e_1_2_8_32_1","first-page":"84","article-title":"Percentage changes in serum pepsinogens are useful as indices of eradication of Helicobacter pylori","volume":"92","author":"Furuta T","year":"1997","journal-title":"Am. 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