{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:24:41Z","timestamp":1767677081385,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":290,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Arrhythmias can be seen as a sign of cardiac autonomic neuropathy in type 1 diabetes mellitus. We aimed to evaluate pulmonary artery pressure, ventricular depolarization and repolarization variability in children with type 1 diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated 78 children with type 1 diabetes mellitus (mean age 11.6\u2009\u00b1\u20093.6\u2009years) and 68 age\u2010gender matched healthy children as control group. All type 1 diabetes mellitus patients were divided into three subgroups according to glycated hemoglobin (HbA1c) levels and the duration of disease. Electrocardiogram and transthoracic echocardiograms were performed on both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with type 1 diabetes mellitus, there was an elongation in P, Pd, PR, QTc, QTd, QTcd, JT, JTc, JTd, Tp\u2010Te and Tp\u2010Te\/QT, Tp\u2010Te\/QTc, Tp\u2010Te\/JT, Tp\u2010Te\/JTc ratios were higher (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In patients with type 1 diabetes mellitus, pulmonary artery pressure was higher than control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Prolongation of QTc, thickness of left ventricle end\u2010diastolic diameter and left ventricle posterior wall diameter were higher in the HbA1c \u22659% subgroup. When adjusted for age there was no significant correlation between left ventricle parameters and HbA1c.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Atrial conduction delay and impairment of ventricular repolarization were significantly high and there was a predisposition for the development of pulmonary artery hypertension in children with type 1 diabetes mellitus. Poor glycemic control was not a risk factor for propensity of left ventricle hypertrophy and left ventricle dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15290","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T16:20:37Z","timestamp":1656519637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ventricular depolarization and repolarization variability in children with type 1 diabetes mellitus"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-5527","authenticated-orcid":false,"given":"Di\u011fdem","family":"Bezen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pediatric Endocrinology University of Health Sciences, Prof. Dr. Cemil Ta\u015f\u00e7\u0131o\u011flu City Hospital  \u0130stanbul 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