{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:57:32Z","timestamp":1772859452713,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":307,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidences of pediatric scurvy has decreased substantially, particularly in developed countries, but there are still reports of it from developing countries. Unusual manifestations have led to delays in diagnosis and treatment. Nevertheless, there are few publications regarding misdiagnosis of scurvy. The objective is to determine dietary factors, clinical manifestations, laboratory and radiologic findings, treatment, and outcomes of scurvy cases. The occurrence of misdiagnosis and its associated factors are also explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The medical records of 0\u201318\u2009year\u2010old children from 2003 to 2016, diagnosed with scurvy, were included and reviewed. Clinical data, and data regarding feeding history, nutritional status, laboratory and radiologic findings, and misdiagnosis were collected. Univariate and logistic regression analysis were used for identification of the independent associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study consisted of 106 children. The boys\u2010to\u2010girls ratio was 2.2:1, and their mean age was 44.65 months \u00b1\u200930.50\u2009months. The common manifestations were refusal to walk, tenderness, and swelling at the lower extremities. Four participants had unusual manifestations including proptosis and scalp hematoma. Low serum vitamin C level and abnormal radiologic findings were detected in most patients. All of them fully recovered after receiving vitamin C supplementation. Misdiagnosis was identified in 74 cases (69%). Logistic regression analysis revealed that temperature higher than or equal to 38 \u00b0C, participants aged 3\u2009years or below, and swelling at lower extremities were independently associated with misdiagnosis (adjusted OR 5.91, 3.78, and 3.56 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Scurvy still exists, and misdiagnosis often occurs. Taking a careful medical history and conducting a physical examination are still the best way to diagnose scurvy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15324","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T04:28:43Z","timestamp":1659932923000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Scurvy in children \u2013 A neglected disease?"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1001-0555","authenticated-orcid":false,"given":"Orawan","family":"Iamopas","sequence":"first","affiliation":[{"name":"Division of Nutrition, Department of Pediatrics Queen Sirikit National Institute of Child Health  Bangkok Thailand"},{"name":"College of Medicine Rangsit University  Mueang Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suntaree","family":"Ratanachu\u2010ek","sequence":"additional","affiliation":[{"name":"Division of Nutrition, Department of Pediatrics Queen Sirikit National Institute of Child Health  Bangkok Thailand"},{"name":"College of Medicine Rangsit University  Mueang Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suranat","family":"Kaewnimee","sequence":"additional","affiliation":[{"name":"Division of Nutrition, Department of Pediatrics Queen Sirikit National Institute of Child Health  Bangkok Thailand"},{"name":"College of Medicine Rangsit University  Mueang Pathum Thani Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"329","volume-title":"Nelson Textbook of Pediatrics","author":"Shah D","year":"2016"},{"key":"e_1_2_8_3_1","first-page":"467","volume-title":"Modern Nutrition in Health and Disease","author":"Jacob RA","year":"1999"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2014.12.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.e55"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.4.e76"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343121"},{"key":"e_1_2_8_8_1","first-page":"25","article-title":"Scurvy in young children","volume":"1","author":"Patanavin P","year":"1995","journal-title":"Thai. 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