{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:08:09Z","timestamp":1792001289235,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Enterococcal infections are increasingly common in hospitalized patients. Enterococcal meningitis\/ventriculitis (EMV) is an extremely rare condition of enterococcal infections, occurring particularly in children. This study investigated the clinical and microbiological characteristics, predisposing factors, and prognosis in pediatric patients with EMV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pediatric patients (&lt;18\u2009years) diagnosed with EMV were retrospectively evaluated over 10\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included a total of 25 isolates from 24 patients, median age 23\u00a0months (range: 1\u2013136\u00a0months). The most common symptoms included vomiting, fever, and headache, with hydrocephalus shunt and preterm birth being the two most common conditions. Commonly associated infections, with central nervous system (CNS) devices as a predisposing factor, were due to external ventricular drainage and ventriculoperitoneal shunts. Two patients with spontaneous meningitis were preterm infant. Of the isolates, 44% were\n                      <jats:italic>Enterococcus faecalis<\/jats:italic>\n                      , 44%\n                      <jats:italic>E.\u00a0faecium<\/jats:italic>\n                      , and 12%\n                      <jats:italic>E.\u00a0gallinarum<\/jats:italic>\n                      . Five (20%) isolates were vancomycin resistant. Twelve patients were resistant to anti\u2010enterococcal antibiotics, including ampicillin, ciprofloxacin, imipenem, teicoplanin, gentamicin, and linezolid (40%, 20%, 8%, 8%, 4%, and 4%, respectively).\n                      <jats:italic>Enterococcus faecium<\/jats:italic>\n                      was more resistant to ampicillin, ciprofloxacin, teicoplanin, and vancomycin than\n                      <jats:italic>E.\u00a0faecalis<\/jats:italic>\n                      . The median treatment duration was 17\u2009days (interquartile range: 14\u201326\u2009days).The mortality rate was 8.3% (2\/24; both associated with vancomycin resistance).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neurosurgical conditions are the most common predisposing factors for EMV. Preterm birth is an important predisposing factor in children. Because EMV is nonspecific in clinical findings, it should be considered when there is an underlying CNS disorder and empirical treatment should begin in this direction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.15398","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T04:19:24Z","timestamp":1666930764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Experience with enterococcal meningitis\/ventriculitis in children"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5803-878X","authenticated-orcid":false,"given":"\u00dcmm\u00fchan","family":"\u00c7ay","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases Faculty of Medicine, \u00c7ukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4809-2883","authenticated-orcid":false,"given":"Derya","family":"Alabaz","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Faculty of Medicine, \u00c7ukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-7645","authenticated-orcid":false,"given":"\u00d6zlem","family":"\u00d6zg\u00fcr G\u00fcnde\u015flio\u011flu","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Faculty of Medicine, \u00c7ukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2983-2399","authenticated-orcid":false,"given":"Filiz","family":"Kibar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine \u00c7ukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6423-7523","authenticated-orcid":false,"given":"Ceren","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Kartal Dr Lutfi K\u0131rdar City Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2420-2734","authenticated-orcid":false,"given":"Kadir","family":"Oktay","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine \u00c7ukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"835","volume-title":"Feigin and Cherry's textbook of pediatric infectious diseases","author":"Chase MNJ","year":"2018"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.3.1.46"},{"key":"e_1_2_12_4_1","unstructured":"MurrayBE MillerWR.Treatment of enterococcal infections[Cited 2022 Jan 15]. 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