{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:22:04Z","timestamp":1781594524721,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate the characteristics of patients with preadolescent\u2010 and adolescent\u2010onset immunoglobulin A vasculitis (IgAV) and to determine whether age affects IgAV outcomes in adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic, clinical, and laboratory data of 333 patients diagnosed with IgAV at the Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, were evaluated retrospectively. The patients were classified into two groups: preadolescents (&lt;10\u2009years) and adolescents (10\u201319\u2009years). Subgroup analyses were also performed by grouping the adolescent patients into early, middle, and late adolescent groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 333 patients, 219 (65.8%) and 114 (34.2%) were preadolescents and adolescents. Palpable purpura, renal, joint, and gastrointestinal (GI) tract involvement were detected in 333 (100%), 78 (23.4%), 79 (23.7%), and 124 (37.2%) patients, respectively; testicular involvement was observed in 25 (13.3%) of 187 male patients. The frequency of renal involvement was significantly higher in the adolescent group than in the preadolescent group at the time of diagnosis (<jats:italic>p<\/jats:italic>\u00a0=\u20090.030). Notably, joint involvement was significantly higher in the adolescent group (<jats:italic>p<\/jats:italic>\u00a0=\u20090.001). The need for aggressive therapy was significantly higher in the adolescent group than in the preadolescent group (<jats:italic>p<\/jats:italic>\u00a0=\u20090.003). There was no significant difference in clinical data, demographic characteristics, and laboratory findings between the adolescent subgroups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immunoglobulin A vasculitis can occur at any age but the disease prognosis appears to worsen with age. The present study reported that joint involvement, kidney involvement, and the need for more aggressive treatment were higher in the adolescent group than in the preadolescent group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15426","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T15:07:50Z","timestamp":1669216070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preadolescent\u2010versus adolescent\u2010onset immunoglobulin A vasculitis: The impact of age on prognosis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2568-9329","authenticated-orcid":false,"given":"Serkan","family":"Co\u015fkun","sequence":"first","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics Ankara City Hospital, University of Health Sciences  Ankara 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