{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:04:40Z","timestamp":1781813080712,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of the pediatric inflammatory multisystem syndrome temporally associated with SARS\u2010CoV\u20102 (PIMS\u2010TS) in low\u2010 and middle\u2010income countries remains poorly understood. Our aim was to understand the characteristics and outcomes of PIMS\u2010TS in Argentina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational, prospective, and retrospective multicenter study enrolled patients younger than 18\u2009years\u2010old manifesting PIMS\u2010TS, Kawasaki disease (KD) or Kawasaki shock syndrome (KSS) between March 2020 and May 2021. Patients were followed\u2010up until hospital discharge or death (one case). The primary outcome was pediatric intensive care unit (PICU) admission. Multiple logistic regression was used to identify variables predicting PICU admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010one percent, 82%, and 14% of the 176 enrolled patients fulfilled the suspect case criteria for PIMS\u2010TS, KD, and KSS, respectively. Temporal association with SARS\u2010CoV\u20102 was confirmed in 85% of the patients and 38% were admitted to the PICU. The more common clinical manifestations were fever, abdominal pain, rash, and conjunctival injection. Lymphopenia was more common among PICU\u2010admitted patients (87% vs. 51%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001), who also showed a lower platelet count and higher plasmatic levels of inflammatory and cardiac markers. Mitral valve insufficiency, left ventricular wall motion alterations, pericardial effusion, and coronary artery alterations were observed in 30%, 30%, 19.8%, and 18.6% of the patients, respectively. Days to initiation of treatment, rash, lymphopenia, and low platelet count were significant independent contributions to PICU admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rates of severe outcomes of PIMS\u2010TS in the present study agreed with those observed in high\u2010income countries. Together with other published studies, this work helps clinicians to better understand this novel clinical entity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15431","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T07:49:57Z","timestamp":1670226597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multicentre observational study on multisystem inflammatory syndrome related to <scp>COVID<\/scp>\u201019 in Argentina"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9828-2776","authenticated-orcid":false,"given":"Eduardo","family":"Vainstein","sequence":"first","affiliation":[{"name":"Cl\u00ednica Pedi\u00e1trica Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Baleani","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Pedi\u00e1trica Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Urrutia","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Pedi\u00e1trica Hospital Nacional de Pediatr\u00eda Juan P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Affranchino","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Pedi\u00e1trica Hospital Nacional de Pediatr\u00eda Juan P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Ackerman","sequence":"additional","affiliation":[{"name":"Unidad de Cardiolog\u00eda Hospital General de Ni\u00f1os Pedro de Elizalde  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Cazalas","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Cardiolog\u00eda Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez y Sanatorio Sagrado Coraz\u00f3n  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Goldsman","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Cardiolog\u00eda Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez y Sanatorio Sagrado Coraz\u00f3n  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Sardella","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Cardiolog\u00eda Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Laura","family":"Tolin","sequence":"additional","affiliation":[{"name":"Servicio de Inmunolog\u00eda Hospital H. 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