{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:56:29Z","timestamp":1783630589099,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":99,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Esophagogastric varices (EGVs) may develop as a result of portal hypertension in children with biliary atresia (BA). Although endoscopic injection sclerotherapy (EIS) with ethanolamine oleate (EO) is reported useful for children, risk factors associated with the presence of high\u2010risk EGVs after treatment remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects were BA patients under 15\u2009years of age who underwent EO\u2010EIS. We retrospectively reviewed a total of 28 treatment sessions of EGVs with red signs and those larger than F2, which were considered to be at high risk of bleeding. Survival analysis was performed for the presence of high\u2010risk EGVs at the time of follow\u2010up endoscopy as the occurrence of an event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate analysis showed a significantly increased risk of the presence of high\u2010risk EGVs post\u2010EO\u2010EIS in patients with increased liver stiffness (LS) and Mac\u20102 binding protein glycan isomer (M2BPGi), with hazard ratios of 1.48 and 1.15, respectively. The median presence\u2010free period was significantly shorter in the LS\u2009\u2265\u20092.8\u00a0m\/s patients than in those with LS\u2009&lt;2.8\u00a0m\/s (189 vs. 266\u2009days). Similarly, the median presence\u2010free period was significantly shorter in patients with M2BPGi\u2009\u2265\u20094.0 than in those with M2BPGi\u2009&lt;\u20094.0 (182 vs. 203\u2009days). The results of multivariate analysis revealed that the risk of the presence of high\u2010risk EGVs was significantly higher only in the high\u2010LS group, with a hazard ratio of 2.76.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased LS is associated with risk of the presence of high\u2010risk EGVs following EO\u2010EIS in children with BA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15454","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T14:10:22Z","timestamp":1671631822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The presence of high\u2010risk varices after sclerotherapy in biliary atresia"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7814-8828","authenticated-orcid":false,"given":"Shinya","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and 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