{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:55:05Z","timestamp":1784544905630,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":99,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term nocturnal enuresis treatment leads to stress and lowered self\u2010esteem for children and their parents. This study evaluated the short\u2010term effectiveness and safety of vibegron (50\u2009mg) for children with refractory nocturnal enuresis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of children with therapy\u2010resistant enuresis was conducted using data for July to December 2019. Enuresis frequency was recorded during 30\u2009days before and after additional vibegron administration with prior treatment. We assessed the treatment effectiveness based on enuresis frequencies between before and after treatment with vibegron 50\u2009mg. Statistical evaluation was performed using a paired <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 29 children receiving vibegron, 14 (48.3%) exhibited a partial or complete response to the drug. Enuresis frequencies (mean \u00b1 standard deviation [SD]) were, respectively, 15.8\u00a0\u00b1\u00a09.2 and 9.5\u00a0\u00b1\u00a09.6 before and after treatment with vibegron during the observed 30\u2009days. A statistically significant reduction in enuresis frequency was found (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). Moreover, maximum mean\u00b1SD morning urine of 200\u00a0\u00b1\u00a062.9\u00a0mL before treatment with vibegron changed to 232\u00a0\u00b1\u200976.6\u00a0mL after treatment. A significant increase in voiding volume in the early morning was found (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05). No drug\u2010related severe adverse event was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Short\u2010term treatment with vibegron is safe and effective for children with refractory enuresis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15464","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T01:08:50Z","timestamp":1672103330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of short\u2010term treatment with vibegron for refractory nocturnal enuresis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6006-4362","authenticated-orcid":false,"given":"Yoshinori","family":"Uchihara","sequence":"first","affiliation":[{"name":"Department of Pediatrics Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumie","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Watanabe Memorial Choumei Research Laboratory  Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9131-0797","authenticated-orcid":false,"given":"Atsuko","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical Research Institute Kitano Hospital, PIIF Tazuke\u2010kofukai  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2006.01217.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2011.03554.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1762-8"},{"key":"e_1_2_8_5_1","unstructured":"The Japanese Society on Enuresis.Clinical Guidelines on Enuresis 2016. [Cited 7 September 2018]. Available from:http:\/\/minds4.jcqhc.or.jp\/minds\/nocturnal\u2010enuresis\/nocturnal\u2010enuresis.pdf(In Japanese)"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-1006-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00305-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2011.08.012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13269"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12158"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14264"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.11.013"},{"issue":"3","key":"e_1_2_8_13_1","first-page":"257","article-title":"A proposal for a classification system of enuresis based on overnight simultaneous monitoring of electroencephalography and cytometry","volume":"12","author":"Watanabe H","year":"1989","journal-title":"Sleep"},{"key":"e_1_2_8_14_1","first-page":"55","article-title":"Clinical outcomes 1 year after vibegron administration, used primarily to treat overactive bladder in pediatric patients with refractory nocturnal enuresis","volume":"27","author":"Hata A","year":"2022","journal-title":"Enuresis"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.15464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.15464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T06:05:24Z","timestamp":1708149924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.15464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/ped.15464"],"URL":"https:\/\/doi.org\/10.1111\/ped.15464","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2022-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15464"}}