{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:37Z","timestamp":1753879357621,"version":"3.41.2"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":115,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute Kawasaki disease (KD) induces central nervous system inflammation and excessive irritability. Long\u2010term impacts on children's neurodevelopment have only been studied marginally. This pilot study aimed to describe the neuropsychological profile of primary school\u2010aged children with a history of KD and to explore the impacts of KD on electroencephalography (EEG) markers associated with attention and brain maturation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen children (8.8\u2009\u00b1\u20092.5\u2009years) were recruited 4.9\u2009\u00b1\u20092.7\u2009years after KD onset. Intellectual abilities, long\u2010term memory, and auditory sustained attention were evaluated. Parents completed standardized questionnaires assessing (1) executive functioning; (2) internalizing and externalizing difficulties; (3) attention deficit hyperactivity disorder symptoms; and (4) autism spectrum disorder symptoms. Theta\/beta ratio (TBR) and alpha peak (AP) were extracted from resting\u2010state EEG and compared with 32 controls (8.9\u2009\u00b1\u20092.1\u2009years). The alpha band was analyzed using a feature reduction algorithm to detect potential groupings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Performances showed preserved intellectual abilities and memory. Sustained attention performance was within the lower range for 4\/14 participants (29%), with considerable parental reports of inattention (43%), working memory difficulties (50%), and hyperactivity\u2010impulsivity (36%). No alterations in the TBR were found but the KD group presented a significantly lower AP amplitude ratio. A clear separation of KD cohort into two clusters showed that acute irritability is associated with a weaker AP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite overall preserved cognitive functions, there is a possible association between KD and attention deficit concerns. This first EEG\u2010based study indicates alpha peak abnormality after KD, predominantly in children with acute irritability. Longitudinal studies are warranted to better characterize patients' neurodevelopmental trajectory.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15482","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T07:34:34Z","timestamp":1674286474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electroencephalography signals and neurodevelopment after Kawasaki disease: A pilot study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0104-4788","authenticated-orcid":false,"given":"Audrey\u2010Ann","family":"Fauteux","sequence":"first","affiliation":[{"name":"Research Center of the Sainte\u2010Justine University Health Center  Montreal Quebec Canada"},{"name":"Department of Psychology University of Montreal  Montreal Quebec 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