{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:30:54Z","timestamp":1787502654388,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:00:00Z","timestamp":1685836800000},"content-version":"vor","delay-in-days":154,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multisystem inflammatory syndrome in children (MIS\u2010C) is hyperinflammation following coronavirus disease 2019 (COVID\u201019), which affects many organs. The retina and choroid are affected by COVID\u201019 through microangiopathy and thrombosis but the literature on MISC\u2010C is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty children (60 eyes) with MIS\u2010C (the study group, or SG) and 32 age\u2010and gender\u2010matched healthy children (64 eyes) (the control group, or CG) were included in the prospective case\u2013control study. Complete ophthalmological examinations, measurements of the vessel densities of the retinal layers, and flow area of the outer retina and choriocapillaris in both groups were conducted with optical coherence tomography angiography (OCT\u2010A).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of the SG was 11.9\u2009\u00b1\u20093.9 and that of the CG was 12.5\u2009\u00b1\u20094.6\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.197). In this study we found that the vessel density of the deep layer of the inner retina was decreased significantly and was reduced in the outer retina of flow area in the SG in comparison with the CG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, for all). However, there was no significant difference between the groups regarding other measurements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In MIS\u2010C patients, vessel densities in the deep layer of the inner retina and in the flow area of the outer retina decreased significantly. This OCTA\u2010A finding suggests that MIS\u2010C is related to endothelial thrombotic condition problems in small branches of the retinal artery. The results of this study support the idea that there is a need for screening of MIS\u2010C patients for the presence of these microangiopathic and perfusional complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.15522","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T09:22:57Z","timestamp":1678440177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of vascular and perfusional changes in the retina and choroid of children with multisystem inflammatory syndrome"],"prefix":"10.1111","volume":"65","author":[{"given":"\u015eamil","family":"Hizli","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Ankara Yildirim Beyazit University, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-3783","authenticated-orcid":false,"given":"Selim","family":"Dereci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zdemir","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Duran","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Hidimo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu \u0130skender","family":"Mazman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belgin","family":"G\u00fclhan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infection Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu \u00c7elikel","family":"Acar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.16420"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2022.0632"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14471"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2021.07.070"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094503"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514573"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1770301"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2021.1909070"},{"key":"e_1_2_9_10_1","first-page":"119","article-title":"B cell responses in hospitalized SARS\u2010CoV\u20102\u2010infected children with and without multisystem inflammatory syndrome","volume":"18","author":"Peart Akindele N","year":"2022","journal-title":"J Infect Dis"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2022.101516"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.3616"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.07.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.3.10"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-021-02059-7"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-020-04935-x"},{"key":"e_1_2_9_17_1","first-page":"11","article-title":"Role of optical coherence tomography angiography in Vogt\u2010Koyanagi\u2010Harada disease","volume":"12","author":"Erba S","year":"2021","journal-title":"GMS Ophthalmol Cases"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12348-019-0190-y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10081386"},{"key":"e_1_2_9_20_1","unstructured":"Centers for Disease Control and Prevention.Multisystem inflammatory syndrome in children (MIS\u2010C) associated with coronavirus disease 2019 (COVID\u201019). 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