{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:39:28Z","timestamp":1768682368218,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":150,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We examined the associations between factors evident at the routine 3\u2010month well\u2010child visit (WCV) and the risk of developing 36\u2010month parent\u2010reported physician\u2010diagnosed bronchial asthma (BA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This longitudinal study was conducted in Nagoya City, Japan, and included 40,242 children who qualified for the 3\u2010month WCVs in the city between April 1, 2016 and March 31, 2018. In total, 22,052 (54.8%) questionnaires linked to their 36\u2010month WCVs were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of BA was 4.5%. The multivariable Poisson regression model identified male sex (adjusted risk ratio [aRR], 1.59; 95% confidence interval [CI]: 1.40\u20131.81), born in autumn (aRR, 1.30; 95% CI: 1.09\u20131.55), having at least one sibling (aRR, 1.31; 95% CI: 1.15\u20131.49), wheeze history before 3\u2010month WCVs, with clinic\/hospital visit: aRR, 1.99; 95% CI: 1.53\u20132.56; hospitalization: aRR, 2.99; 95% CI: 2.09\u20134.12, eczema with itch (aRR, 1.51; 95% CI: 1.27\u20131.80), paternal history of BA (aRR, 1.98; 95% CI: 1.66\u20132.34), maternal history of BA (aRR, 2.11; 95% CI: 1.77\u20132.49), and rearing pets with fur (aRR, 1.35; 95% CI: 1.15\u20131.58) were independent risk factors for BA at 36\u00a0months of age. The combination of severe wheeze history (with clinic\/hospital visit or hospitalization) and maternal and paternal BA could identify high\u2010risk infants whose prevalence of BA was 20%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combined assessment of important clinical factors enabled us to identify high\u2010risk infants set to derive optimal benefit from health guidance provided to the parent or caregiver of the child or infant at WCVs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15530","type":"journal-article","created":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T07:00:00Z","timestamp":1679122800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical risk factors at 3 months of age for the development of bronchial asthma at 36 months of age"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-2704","authenticated-orcid":false,"given":"Shiro","family":"Sugiura","sequence":"first","affiliation":[{"name":"Department of Allergy, Allergy and Immunology Center Aichi Children's Health and Medical Center  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimichi","family":"Hiramitsu","sequence":"additional","affiliation":[{"name":"Nagoya City Public Health Research Institute  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-9649","authenticated-orcid":false,"given":"Masaki","family":"Futamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Nagoya Medical Center  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Kamioka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nagoya City University West Medical Center  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4776-2438","authenticated-orcid":false,"given":"Chikae","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Nursing Kinjo Gakuin University  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harue","family":"Umemura","sequence":"additional","affiliation":[{"name":"School of Nutritional Sciences Nagoya University of Arts and Sciences  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuto","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fujita Health University Bantane Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Komei","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Allergy, Allergy and Immunology Center Aichi Children's Health and Medical Center  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2020.02.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12917"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_8_5_1","first-page":"1","article-title":"Epidemiology standardization project (American Thoracic Society)","volume":"118","author":"Ferris BG","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.O-08-550"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21557"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01021.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199008233230802"},{"key":"e_1_2_8_10_1","unstructured":"Global Initiative for Asthma.Global strategy for asthma management and prevention[page on the internet].c2020. 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