{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:26:28Z","timestamp":1787495188992,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":190,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tolvaptan (TLV) is a selective vasopressin receptor 2 antagonist administered for congestive heart failure (CHF) after inadequate response to other diuretics. The effectiveness and safety of TLV have been evaluated well in adult patients. However, reports on its use in pediatric patients, especially infants, are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively evaluated 41 children younger than\u20091\u2009year of age who received TLV for CHF for congenital heart disease (CHD) between January 2010 and August 2021. We monitored the occurrence of adverse events, including acute kidney injury and hypernatremia, as well as laboratory data trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 41 infants included, 51.2% were male. The median age when TLV was initiated was 2 months, interquartile range (IQR) 1\u20134 months, and all infants had been administered other diuretics previously. The median dose of TLV was 0.1 mg\/kg\/day (IQR, 0.1\u20130.1). Urine output increased significantly after 48\u2009h of treatment: baseline, 315 mL\/day (IQR, 243\u2013394); 48\u2009h, 381 mL\/day (IQR, 262\u2013518)\u2009,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0004; 72\u2009h, 385 mL\/day (IQR, 301\u2013569),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0013; 96\u2009h, 425 mL\/day (IQR, 272\u2013524),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0006; and 144\u2009h, 396 mL\/day (IQR, 305\u2013477),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0036. No adverse events were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tolvaptan can be used safely and efficiently in infants with CHD. From the perspective of adverse effects, initiating administration at a lower dosage is preferable because this was found to be sufficiently effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.15580","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T14:09:50Z","timestamp":1688998190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and safety of Tolvaptan in infants with congenital heart disease"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-3812","authenticated-orcid":false,"given":"Haruhide","family":"Sakaguchi","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2398-5928","authenticated-orcid":false,"given":"Daishi","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Takemasa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Umeda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9446-8912","authenticated-orcid":false,"given":"Kimihiko","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.08.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.820217"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.07.023"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-011-6350-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.12.1319"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.12.1332"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp253"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2013.04.001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009080857"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000070422.41439.04"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065181"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02950319"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-017-1693-x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0671-y"},{"key":"e_1_2_8_19_1","unstructured":"Japanese Circulation Society Joint Working Group.JCS 2018 guideline on the clinical examinations for decision making of diagnosis and drug therapy in pediatric patients with congenital heart disease and cardiovascular disorder [in Japanese]. 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