{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:53:38Z","timestamp":1792047218605,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":243,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the efficacy and safety of anti\u2010interleukin\u20101 (IL\u20101) therapies in colchicine\u2010resistant pediatric patients with familial Mediterranean fever (FMF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we retrospectively evaluated 656 children with FMF and 27 patients who had been treated with anti\u2010IL\u20101 therapies (anakinra\/canakinumab) . Clinical and laboratory features, <jats:italic>MEFV<\/jats:italic> gene mutations, treatment responses were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty of the patients were treated with anakinra (the treatment of 6 patients who initially used anakinra was switched to canakinumab in the follow\u2010up period), and 13 patients were treated with canakinumab. Clinical symptom and severity scores decreased in all patients A decrease in acute phase reactants was also observed in patients. A total of 18 (66%) patients had a <jats:italic>M694V<\/jats:italic> homozygous mutation, while 24 (89%) patients had a <jats:italic>M694V<\/jats:italic> mutation, at least in one allele.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FMF patients with colchicine resistance may progress to amyloidosis. IL\u20101 antagonist treatment could be used safely with a favorable outcome in pediatric patients with FMF resistance to colchicine therapy and\/or who have renal amyloidosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15588","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:22:22Z","timestamp":1693632142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of anti\u2010interleukin\u20101 in children with colchicine\u2010resistant familial Mediterranean fever"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1095-4732","authenticated-orcid":false,"given":"Hatice Kubra","family":"Erkilet","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Gazi University  Ankara 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