{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:28:44Z","timestamp":1769117324541,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":235,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Objective investigation of the characteristics of acute bronchiolitis in infants is important for its diagnosis and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lung sound data of 50 patients diagnosed with respiratory syncytial virus (RSV) acute bronchiolitis (m:f\u2009=\u200929:21, median of age 7\u2009months), 20 patients with RSV acute respiratory tract infections without acute bronchiolitis (m:f\u2009=\u200910:10, 5\u2009months) and 38 age\u2010matched control infants (m:f\u2009=\u200923:15, 8\u2009months) were analyzed using a conventional method and compared. Furthermore, the relationships between lung sound parameters and clinical symptoms (clinical score, length of hospital stay and SpO<jats:sub>2<\/jats:sub> level) in the bronchiolitis and the non\u2010bronchiolitis patients were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results of lung sound analysis showed that the inspiratory sound power of patients with RSV respiratory tract infections was low and the expiratory sound power was high compared with those of the controls. When the patients with RSV respiratory tract infections were divided into the bronchiolitis and non\u2010bronchiolitis groups, the expiratory\/inspiratory ratio of the bronchiolitis patients was greater than that of the non\u2010bronchiolitis patients. There was no difference in the clinical symptoms, clinical score and length of hospital stay between the bronchiolitis and non\u2010bronchiolitis patients, except for the SpO<jats:sub>2<\/jats:sub> level on admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lung sound analysis confirmed that patients with RSV acute bronchiolitis present with marked airway narrowing. Considering these results as a characteristic of acute bronchiolitis, it would be meaningful to reflect it in the improvement of diagnosis, treatment and subsequent management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15605","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T12:07:13Z","timestamp":1692878833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical application of a lung sound analysis in infants with respiratory syncytial virus acute bronchiolitis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-6203","authenticated-orcid":false,"given":"Mami","family":"Ichinose","sequence":"first","affiliation":[{"name":"Department of Pediatrics Tokai University Hachioji Hospital  Hachioji Japan"},{"name":"Tokyo Metropolitan Children's Medical Center  Fuchu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeru","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University Hachioji Hospital  Hachioji Japan"},{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University Hachioji Hospital  Hachioji Japan"},{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University Hachioji Hospital  Hachioji Japan"},{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sakama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University Hachioji Hospital  Hachioji Japan"},{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Takakura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University Hachioji Hospital  Hachioji Japan"},{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University Hachioji Hospital  Hachioji Japan"},{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Furuya","sequence":"additional","affiliation":[{"name":"Department of Basic Clinical Science and Public Health Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-8552","authenticated-orcid":false,"given":"Masahiko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University Hachioji Hospital  Hachioji Japan"},{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5273-1820","authenticated-orcid":false,"given":"Hiroyuki","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University Hachioji Hospital  Hachioji Japan"},{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-052089"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900544"},{"key":"e_1_2_10_5_1","article-title":"Nebulised hypertonic saline solution for acute bronchiolitis in infants","volume":"12","author":"Zhang L","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1699-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9906076"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513737"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2015.07.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2016.11.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.07.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2742"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/19.9.485"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26034"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1990.tb02431.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70044-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2018.05.004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.02.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2017.02.016"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-019-03363-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-020-02211-y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.3.9701115"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.12.1285"},{"key":"e_1_2_10_24_1","first-page":"597","article-title":"Definition of terms for applications of respiratpry sounds","volume":"10","author":"Sovijarvi ARA","year":"2000","journal-title":"Eur Respir Rev"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16d04.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800725"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.23.1.7"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08111942"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25799"},{"key":"e_1_2_10_30_1","unstructured":"Global Initiative for Asthma.Global Strategy for Asthma Management and Prevention [cited 2023 Jan 12]. Available from:http:\/\/ginasthma.org\/gina\u2010reports\/ 2022 GINA\u2010Main\u2010Report"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.15605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T05:53:34Z","timestamp":1708149214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.15605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/ped.15605"],"URL":"https:\/\/doi.org\/10.1111\/ped.15605","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2023-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15605"}}