{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:40:59Z","timestamp":1753879259092,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":254,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus (SLE). The aim of this study was to identify serum insulin\u2010like growth factor binding protein\u20102 (IGFBP\u20102) as a novel non\u2010invasive biomarker for clinical disease and renal pathology in pediatric LN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study on 93 newly diagnosed LN children who were biopsy\u2010proven, 35 SLE children with no renal involvement as disease controls, and 30 healthy controls (HC) with age and gender\u2010matched. All children were ELISA tested for serum IGFBP\u20102 levels. Clinical, laboratory, histopathological features of LN patients were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to SLE or HC, serum IGFBP\u20102 levels were significantly elevated in LN patients. Serum IGFBP\u20102 could distinguish LN patients from two others (AUC\u2009=\u20090.937, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for LN vs. HC; 0.897, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 for LN vs. SLE). In ROC analysis, IGFBP\u20102 had a higher ability to differentiate between LN and SLE than anti\u2010dsDNA with AUC values of 0.895 and 0.643, respectively. LN children with systemic lupus erythematosus disease activity index (SLEDAI) in high activity had significantly higher IGFBP\u20102 concentration than the others with SLEDAI in moderate activity. Serum IGFBP\u20102 correlated with albuminemia levels (<jats:italic>r<\/jats:italic>\u2009=\u20090.415, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), urine protein\u2010to\u2010creatinine levels (<jats:italic>r<\/jats:italic>\u2009=\u20090.316, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), estimated glomerular filtration rate (<jats:italic>r<\/jats:italic>\u2009=\u20090.438, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), complement C3 (<jats:italic>r<\/jats:italic>\u2009=\u20090.333, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). More importantly, serum IGFBP\u20102 correlated with the activity index of renal pathology (<jats:italic>r<\/jats:italic>\u2009=\u20090.312, <jats:italic>p<\/jats:italic>\u2009=\u20090.007, <jats:italic>n<\/jats:italic>\u2009=\u200975).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum IGFBP\u20102 is a promising biomarker for pediatric lupus nephritis, reflective of disease activity and activity index in renal patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15613","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T11:20:56Z","timestamp":1694517656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insulin\u2010like growth factor binding protein\u20102 as a biomarker for lupus nephritis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7412-4039","authenticated-orcid":false,"given":"Phuong Thi","family":"Luong","sequence":"first","affiliation":[{"name":"Hanoi Medical University  Hanoi Vietnam"},{"name":"Vietnam National Children's Hospital  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy Thi Dieu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hanoi Medical University  Hanoi Vietnam"},{"name":"Vietnam National Children's Hospital  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngoc Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vietnam National Children's Hospital  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang Thu","family":"Ngo","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huy Ngoc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hanoi Medical University  Hanoi Vietnam"},{"name":"Vietnam National Children's Hospital  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diep Hong","family":"Pho","sequence":"additional","affiliation":[{"name":"Vietnam National Children's Hospital  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huong Thu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vietnam National Children's Hospital  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.121"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2012.03.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.09.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000224709.70133.f7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.12.1065"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.08.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151491"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.7166"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3912"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.021667"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4095"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318756288"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3720"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2004.10.014"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00905"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203319846388"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/2175-8239-jbn-2018-0097"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v3.i2.16"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.002469"},{"issue":"24","key":"e_1_2_9_22_1","first-page":"8601","article-title":"Insulin\u2010like 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