{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:49:53Z","timestamp":1781632193815,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":277,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Hypoglycemia is a significant problem for all neonates and requires minimally invasive and reliable monitoring. The primary objective of this study was to verify the safety and accuracy of the continuous glucose monitoring (CGM) of full\u2010term neonates using Freestyle Libre, a flash glucose monitoring (FGM) device.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study was conducted on 20 neonates. Shortly after birth, we placed the FGM sensor on the outside of the neonates' thighs. We scanned the CGM values at 60, 120, 180, and 360\u2009min after birth and simultaneously obtained blood glucose values with plantar capillaries by heel puncture. The neonates wore the sensors for up to 6\u2009h and then they were removed.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 75 data points to be measured, 65 points (86.7%) were obtained by scan. There was no change in the sensor attachment site in 12 of 18 completed cases in this study but we observed slight induration in four cases (22.2%) and slight redness in one case (5.5%) at the sensor puncture site. A moderate correlation was observed between the CGM and blood glucose values. The CGM values tended to be low at 120, 180, and 360\u2009min after birth, and tended to be high only at 60\u2009min after birth.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The CGM device was safe to wear on the neonate and the CGM data correlated well with blood glucose levels. There was dissociation between CGM data and blood glucose levels in the acute period soon after birth when the blood glucose levels changed rapidly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15616","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T11:28:29Z","timestamp":1696505309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and accuracy of neonatal continuous glucose monitoring"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7168-8493","authenticated-orcid":false,"given":"Akira","family":"Ohishi","sequence":"first","affiliation":[{"name":"Maternal\u2010Fetal and Neonatal Care Center Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daizo","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Regional Neonatal and Perinatal Medicine Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoka","family":"Fujita","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal and Neonatal Care Center Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0003-027X","authenticated-orcid":false,"given":"Yuki","family":"Segawa","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal and Neonatal Care Center Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal and Neonatal Care Center Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Regional Neonatal and Perinatal Medicine Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.5.1141"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.1631"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.014"},{"key":"e_1_2_8_5_1","unstructured":"Freestyle\u00ae Libre package insert(Last accessed: 11\/Nov\/2022)https:\/\/www.info.pmda.go.jp\/downfiles\/md\/PDF\/100159\/100159_22800BZX00212000_B_01_07.pdf(The latest Japanese text is available on PMDA (and MAH) website)"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.10.5.622"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2012.03728.x"},{"key":"e_1_2_8_8_1","first-page":"59","article-title":"A study of the continuous glucose monitoring (CGM) in preterm infants at NICU","volume":"27","author":"Nakamura T","year":"2015","journal-title":"J Jpn Soc Premat Newborn Med"},{"key":"e_1_2_8_9_1","first-page":"57","article-title":"A study of the utility of continuous glucose monitoring (CGM) in the NICU: the 2nd report; 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