{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T21:38:01Z","timestamp":1783028281437,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":330,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Less invasive surfactant administration (LISA) results in less need for mechanical ventilation and a reduction in death, bronchopulmonary dysplasia, and intraventricular hemorrhage as outcomes. This study aimed to evaluate the efficacy and short\u2010term outcomes of surfactant administration by the LISA method using an 5F infant feeding tube in preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During the period from May, 2019 to August, 2022, we carried out a prospective observational study that included all premature infants with respiratory distress syndrome who were admitted to our neonatal intensive care unit. The study involved collecting and analyzing data on the procedural efficacy of LISA, vital parameters, and short\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study included a total of 110 infants with an average gestational age of 30.9\u2009\u00b1\u20091.9\u2009weeks and a mean birthweight of 1347.5\u2009\u00b1\u2009354.1\u2009g. Of these infants, two required intubation during the LISA procedure, whereas 11 infants required intubation within 72\u2009h after LISA. Infants with a higher pre\u2010surfactant fraction of inspired oxygen (F<jats:sub>i<\/jats:sub>O<jats:sub>2<\/jats:sub>) requirement, an elevated Score for Neonatal Acute Physiology with Perinatal Extension (SNAPPE), and the presence of sepsis were associated with the need for intubation within the first 72\u2009h of life. Thirty\u2010one infants also experienced a drop in saturation of peripheral oxygen (SpO<jats:sub>2<\/jats:sub>) below 80% for more than 1\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Less invasive surfactant administration was feasible and safe to administer via an orotracheally introduced 5F infant feeding tube in non\u2010invasive ventilation to support spontaneously breathing infants between 28<jats:sup>+0<\/jats:sup> and 33<jats:sup>+6<\/jats:sup>\u2009weeks of gestation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15668","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T23:47:31Z","timestamp":1701128851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Experience of less invasive surfactant administration with a 5F infant feeding tube in a tertiary center of low\u2010 and middle\u2010income countries"],"prefix":"10.1111","volume":"65","author":[{"given":"Md Habibullah","family":"Sk","sequence":"first","affiliation":[{"name":"Department of Neonatology Institute of Post Graduate Medical Education &amp; Research and SSKM Hospital  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-9225","authenticated-orcid":false,"given":"Bijan","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Neonatology Institute of Post Graduate Medical Education &amp; Research and SSKM Hospital  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"CD000510","article-title":"Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants","volume":"3","author":"Rojas\u2010Reyes MX","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_3_1","unstructured":"WHO [Internet].Preterm birth.2018.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/preterm\u2010birth. 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