{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:55Z","timestamp":1753879375026,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":299,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL34788"],"award-info":[{"award-number":["HL34788"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Interactions among single nucleotide polymorphisms (SNPs) of surfactant protein (SP) are associated with acute respiratory failure (ARF) and its short\u2010term outcome, pulmonary dysfunction at discharge (PDAD) in children. However, genetic association studies using individual SNPs have not been conducted before. We hypothesize that SP genetic variants are associated with pediatric ARF and its short\u2010term complications by themselves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used available genotype and clinical data in the Floros biobank consisting of 248 children aged \u226424\u2009months with ARF; 86 developed PDAD. A logistic regression analysis was performed for each of the 14 selected SNPs, SP\u2010A1 and SP\u2010A2 genotypes. A <jats:italic>p<\/jats:italic>\u2010value less than the Bonferroni correction threshold was considered significant. A likelihood ratio test was done to compare two models (one with demographic data and another with genetic variants).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before Bonferroni correction, female sex is associated with a decreased risk of ARF. Black race and the rs721917 of the <jats:italic>SFTPD<\/jats:italic> are associated with increased risk of ARF. After Bonferroni correction, the 1A<jats:sup>0<\/jats:sup>1A<jats:sup>1<\/jats:sup> genotype of <jats:italic>SFTPA2<\/jats:italic> was associated with decreased risk of ARF. The likelihood ratio test showed that the model of the genotype information with demographic data was a better fit to predict ARF risk. None of the SP SNPs and SP\u2010A1, SP\u2010A2 genotypes were associated with PDAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate that SNPs and genotypes of SPs involved in innate immunity and host defense play an important role in ARF and, in the future, may be used as biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.15672","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T11:12:04Z","timestamp":1698405124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of surfactant protein <scp>A2<\/scp> with acute respiratory failure in children"],"prefix":"10.1111","volume":"65","author":[{"given":"Lucy","family":"Emery","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Pennsylvania State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Pennsylvania State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keenan","family":"Anderson\u2010Fears","sequence":"additional","affiliation":[{"name":"Department of Public Health Science The Pennsylvania State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Public Health Science The Pennsylvania State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Floros","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Pennsylvania State College of Medicine  Hershey Pennsylvania USA"},{"name":"Department of Obstetrics &amp; Gynecology The Pennsylvania State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-7074","authenticated-orcid":false,"given":"Chintan K.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Pennsylvania State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3928\/19382359-20180625-01"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30344-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.766719"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.681639"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2350\/09-01-0586.1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/1999\/961430"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02256"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2000.580305.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.682160"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.588404"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.842745"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.922956"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/315866"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041183"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.815727"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.09.043"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005287"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00241.2002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13934"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10030"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-68748-9_14"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/CC11355"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902148.2011.654045"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819292ea"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200206000-00006"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.06.005"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01543"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.4.470"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0761-y"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.15672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T06:01:12Z","timestamp":1708149672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.15672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/ped.15672"],"URL":"https:\/\/doi.org\/10.1111\/ped.15672","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"type":"print","value":"1328-8067"},{"type":"electronic","value":"1442-200X"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2023-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15672"}}