{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T20:27:37Z","timestamp":1764448057996,"version":"3.46.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":92,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human milk (HM) has been proven to provide immunological and nutritional advantages to neonates; however, acquired cytomegalovirus (CMV) infection can be associated with raw HM. In Japan, there are no standardized guidelines concerning HM handling. This cross\u2010sectional survey was performed to reveal specific trends in HM handling in neonatal intensive care units (NICUs) in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A questionnaire was sent to 255 NICUs participating in the Japanese Neonatologist Association in May 2020. It involved HM handling practices, such as maternal screening, pasteurization, storage, and the workforce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 255 NICUs, 174 (67.8%) responded to the survey. Maternal CMV screening was carried out in 37\u2009units (22.2%), and CMV inactivation in HM was performed in 44\u2009units (26.5%). For CMV inactivation, a freeze\u2010thawing method was employed in about 90% of units. In 70% of units providing CMV inactivation, CMV inactivation was conducted regardless of bodyweight and corrected gestational age of infants until the infants' discharge. Acquired CMV infection in preterm neonates was observed in 43\u2009units (25.7%) in the survey period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A wide range of HM handling practices are used in Japanese NICUs. A national guideline for handling HM in NICUs should be created to promote the infection control of CMV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.15728","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T09:54:39Z","timestamp":1712051679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Handling of human milk to prevent acquired cytomegalovirus infection in Japanese neonatal intensive care units: The first nationwide survey"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7781-1870","authenticated-orcid":false,"given":"Kana","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Pediatrics Saitama Medical Center, Saitama Medical University  Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Saitama Medical Center, Saitama Medical University  Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Saitama Medical Center, Saitama Medical University  Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Saitama Medical Center, Saitama Medical University  Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-0565","authenticated-orcid":false,"given":"Mitsuhiro","family":"Haga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Saitama Medical Center, Saitama Medical University  Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Saitama Medical Center, Saitama Medical University  Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Kabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Saitama Medical Center, Saitama Medical University  Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Namba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Saitama Medical Center, Saitama Medical University  Kawagoe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060707"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2117"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80533-3"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02538.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-303384"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.11.002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.4532"},{"key":"e_1_2_12_9_1","unstructured":"Agence Francaise de Se'curite\u00b4 Sanitaire des Aliments.Recommandations d'hygie'ne pour la preparation et la conservation des biberons.2005. 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