{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:04:27Z","timestamp":1791497067820,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"vor","delay-in-days":110,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      This study aimed to assess the validity of the oxygenation saturation index (OSI) and the ratio of oxygen saturation to the fraction of inspired oxygen (F\n                      <jats:sub>I<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      ) (S\/F ratio) with percutaneous oxygen saturation (OSI\n                      <jats:sub>SpO2<\/jats:sub>\n                      and the S\n                      <jats:sub>p<\/jats:sub>\n                      \/F ratio) and to evaluate the correlation between these values and the oxygen index (OI). It also determined their cut\u2010off values for predicting OI in accordance with neonatal hypoxic respiratory failure severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed the data of 77 neonates (gestational age 31.7\u2009\u00b1\u20096.1\u2009weeks; birthweight, 1768\u2009\u00b1\u2009983\u2009g) requiring invasive mechanical ventilation between 2013 and 2020, 1233 arterial blood gas samples in total. We calculated the OI, OSI\n                      <jats:sub>SpO2<\/jats:sub>\n                      , OSI with arterial oxygen saturation (SaO\n                      <jats:sub>2<\/jats:sub>\n                      ) (OSI\n                      <jats:sub>SaO2<\/jats:sub>\n                      ), S\n                      <jats:sub>p<\/jats:sub>\n                      \/F ratio, and the ratio of SaO\n                      <jats:sub>2<\/jats:sub>\n                      to F\n                      <jats:sub>I<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      (S\n                      <jats:sub>a<\/jats:sub>\n                      \/F ratio).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The regression and Bland\u2013Altman analysis showed good agreement between OSI\n                      <jats:sub>SpO2<\/jats:sub>\n                      or the S\n                      <jats:sub>p<\/jats:sub>\n                      \/F ratio and OSI\n                      <jats:sub>SaO2<\/jats:sub>\n                      or the S\n                      <jats:sub>a<\/jats:sub>\n                      \/F ratio. Although a significant positive correlation was found between OSI\n                      <jats:sub>SpO2<\/jats:sub>\n                      and OI, OSI\n                      <jats:sub>SpO2<\/jats:sub>\n                      was overestimated in SpO\n                      <jats:sub>2<\/jats:sub>\n                      \u2009&gt;\u200998% with a higher slope of the fitted regression line than that below 98% of SpO\n                      <jats:sub>2<\/jats:sub>\n                      . Furthermore, receiver\u2010operating characteristic curve analysis using only SpO\n                      <jats:sub>2<\/jats:sub>\n                      \u2009\u2264\u200998% samples showed that the optimal cut\u2010off points of OSI\n                      <jats:sub>SpO2<\/jats:sub>\n                      and the S\n                      <jats:sub>p<\/jats:sub>\n                      \/F ratio for predicting OI were: OI 5, 3.0 and 332; OI 10, 5.3 and 231; OI 15, 7.7 and 108; OI 20, 11.0 and 149; and OI 25, 17.1 and 103, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The cut\u2010off OSI\n                      <jats:sub>SpO2<\/jats:sub>\n                      and S\n                      <jats:sub>p<\/jats:sub>\n                      \/F ratio values could allow continuous monitoring for oxygenation changes in neonates with the potential for wider clinical applications.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.15753","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T04:09:20Z","timestamp":1713586160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oxygenation saturation index in neonatal hypoxemic respiratory failure"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-5318","authenticated-orcid":false,"given":"Shinichiro","family":"Tsurukawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Japan"},{"name":"Department of Pediatrics Nagasaki Kamigoto Hospital  Nagasaki Japan"},{"name":"Department of Pediatrics, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7055-3554","authenticated-orcid":false,"given":"Masashi","family":"Zuiki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Japan"},{"name":"Department of Pediatrics, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Japan"},{"name":"Department of Pediatrics, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Japan"},{"name":"Department of Pediatrics, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utsuki","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Japan"},{"name":"Department of Pediatrics Nagasaki Kamigoto Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9725-1102","authenticated-orcid":false,"given":"Takuyo","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Japan"},{"name":"Department of Pediatrics, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Ichise","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Hospital Organization Maizuru Medical Center  Maizuru Japan"},{"name":"Department of Pediatrics, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Horiguchi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Teramukai","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kyoto 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