{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:57:01Z","timestamp":1781139421941,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":162,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immumoglobulin A (IgA) vasculitis (IgAV), formerly known as Henoch\u2013Sch\u00f6nlein purpura (HSP), is a self\u2010limiting systemic vasculitis in children. Kidney involvement is associated with a long\u2010term unfavorable outcome and can lead to significant morbidity. This study was conducted to describe the clinical and laboratory characteristics of childhood IgAV with kidney involvement and to identify risk factors associated with IgAV nephritis (IgAVN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an ambidirectional descriptive study of 77 children with IgAV. All demographic data, clinical features, and laboratory tests were collected from electronic medical records from January 2010 to December 2022. Risk factors for kidney involvement in IgAV were assessed using multivariate logistic regression. Kaplan\u2013Meier survival analysis was used to calculate the time to commencement of kidney involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010five children (32.4% of the IgAV patients) developed IgAVN. The common findings in IgAV with kidney involvement were microscopic hematuria (100%), nephrotic range proteinuria (44%), and non\u2010nephrotic range proteinuria (40%). Multivariate logistic regression showed that age greater than 10\u2009years (adjusted hazard ratio, AHR 4.66; 95% confidence interval, CI, 1.91\u201311.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), obesity (body mass index, BMI,\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score\u2009\u2265\u2009+2 standard deviations, SDs) (AHR 3.59; 95% CI 1.41\u20139.17;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), and hypertension at onset (AHR 4.78; 95% CI 1.76\u201312.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) were associated significantly with kidney involvement. During follow up, most IgAV patients developed nephritis within the first 9\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Age greater than 10\u2009years, obesity, and hypertension at presentation were predictive factors for IgAVN. Our study emphasized that IgAV patients with risk factors should be closely monitored for at least 1 year after the onset of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.15781","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T02:34:40Z","timestamp":1718159680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical characteristics and risk factors for kidney involvement in children with immunoglobulin\n                    <scp>A<\/scp>\n                    vasculitis"],"prefix":"10.1111","volume":"66","author":[{"given":"Boonyapohn","family":"Chatpaitoon","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Chulalongkorn University, King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornpimol","family":"Rianthavorn","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, Faculty of Medicine Chulalongkorn University, King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9382-8151","authenticated-orcid":false,"given":"Ankanee","family":"Chanakul","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, Faculty of Medicine Chulalongkorn University, King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-3887","authenticated-orcid":false,"given":"Parichat","family":"Khaosut","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Faculty of Medicine, Center of Excellence for Allergy and Clinical Immunology Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-021-00616-z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.10.009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.126"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3339\/jkspn.2020.24.1.1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-021-05086-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167346"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2019.1685545"},{"key":"e_1_2_11_9_1","first-page":"204","article-title":"Predictive factor of 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