{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:48:22Z","timestamp":1775486902583,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":352,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to evaluate whether an early elevation of absolute eosinophil count after allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) was associated with the development of chronic graft\u2010versus\u2010host disease (cGVHD) in children and adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 165 consecutive patients who received allo\u2010HSCT were included in the study. Patients who had previously received allo\u2010HSCT, relapsed or died before Day 100, and did not achieve engraftment, were excluded. Eosinophilia was defined as an eosinophil count exceeding 500\/\u03bcL in peripheral blood within 60\u2009days of stem cell infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eosinophilia was observed in 67 patients (40.6%). There were no significant differences in disease type, graft source, donor type, conditioning regimen, and GVHD prophylaxis and treatment between the patients with or without eosinophilia. The 3\u2010year cumulative incidence rate of cGVHD in the entire cohort was 39.3% (95% confidence interval (CI): 32.2\u201347.4). Patients with eosinophilia had a higher 3\u2010year cumulative incidence rate of cGVHD compared to those without eosinophilia (49.1% vs. 32.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Cox proportional hazards model analysis revealed that eosinophilia was associated with an increased risk of cGVHD (adjusted hazard ratio: 2.12; 95% CI: 1.16\u20133.85,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early eosinophilia after allo\u2010HSCT may serve as a predictor for the development of cGVHD in children and adolescents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.15836","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T06:50:49Z","timestamp":1734504649000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early eosinophilia after hematopoietic stem cell transplantation is associated with chronic graft\u2010versus\u2010host disease"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7461-9138","authenticated-orcid":false,"given":"Suguru","family":"Uemura","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Kobe Children's Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kobe Children's Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Fujikawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kobe Children's Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Kobe Children's Hospital  Kobe 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