{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:57:41Z","timestamp":1790913461170,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004053","name":"Masato Kawano Memorial Public Interest Foundation for Promotion of Pediatrics","doi-asserted-by":"publisher","award":["COVID\u201019\u20107"],"award-info":[{"award-number":["COVID\u201019\u20107"]}],"id":[{"id":"10.13039\/501100004053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to reveal the transmission rate of coronavirus disease 2019 (COVID\u201019) and clinical features of congenital and neonatal COVID\u201019 and to disclose the efficacy of maternally transferred antibodies by maternal vaccination against severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, prospective observational study included a comprehensive testing protocol with appropriate precautions. Mothers and infants were enrolled and classified into an active infection group (mothers with COVID\u201019 at delivery), a postinfection group (mothers recovered from COVID\u201019 during pregnancy), and a vaccination group (mothers vaccinated during pregnancy). Specimen collections, polymerase chain reaction assays, anti\u2010SARS\u2010CoV\u20102 antibody measurements, and clinical examinations were conducted for 6\u2009months from delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010nine mothers and 70 infants were enrolled. SARS\u2010CoV\u20102 was detected in the placenta in 22% of the active infection group and in 21% of the postinfection group. Neither SARS\u2010CoV\u20102 nor SARS\u2010CoV\u20102\u2010specific IgM was detected in infants. No anomalies, functional disorders, or developmental problems were observed in infants for 6\u2009months. Compared with the postinfection group, there was a significant increase in maternally transferred antibody titers in the vaccination group according to the number of vaccinations, which was maintained for longer than the first month of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vertical transmission of COVID\u201019 was not observed despite a comprehensive testing protocol. SARS\u2010CoV\u20102 was detected more often in the placenta, which appeared to prevent vertical transmission. Maternal vaccination increased maternally transferred antibody titers in infants and was considered immunologically efficient. Vaccination during pregnancy is considered important for preventing congenital, neonatal, and infantile COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.15892","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:06:34Z","timestamp":1741723594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rate of vertical transmission of coronavirus disease 2019 and effect of maternal vaccination: A prospective cohort study"],"prefix":"10.1111","volume":"67","author":[{"given":"Satoshi","family":"Matsunashi","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Center for Global Health and Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Unoki\u2010Kubota","sequence":"additional","affiliation":[{"name":"Department of Diabetic Complications, Diabetes Research Center, Research Institute National Center for Global Health and Medicine  Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolism Information Center, Research Institute National Center for Global Health and Medicine  Shinjuku\u2010ku Tokyo Japan"},{"name":"Institute for Global Health Policy Research, Bureau of International Health Cooperation National Center for Global Health and Medicine  Shinjuku\u2010ku Tokyo Japan"},{"name":"Department of Health Services Research, Institute of Medicine University of Tsukuba  Tsukuba\u2010shi Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Disease Control and Prevention Center National Center for Global Health and Medicine  Shinjuku\u2010ku Tokyo 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Fuchu\u2010shi Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8727-7613","authenticated-orcid":false,"given":"Kohei","family":"Kashima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Tokyo Hospital  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Neonatology Toho University Omori Medical Center  Ota\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4097-5104","authenticated-orcid":false,"given":"Yayoi","family":"Murano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokyo Metropolitan Toshima Hospital  Itabashi\u2010ku Tokyo 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