{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:58:31Z","timestamp":1790913511549,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":133,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In Japan, the administration of extra\u2010hypotonic fluids (approximately 35\u2009mmol\/L of sodium) as maintenance fluid is still the mainstream practice, and there have been relatively few reports on maintenance intravenous fluid therapy. Since 2014, our institution has administered maintenance fluids containing 83\u2009mmol\/L of Na (HALF) after diuresis is achieved post\u2010Kasai portoenterostomy for biliary atresia (BA). We investigated whether hyponatremia is induced by the administration of half saline during postoperative maintenance of infants with BA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent surgery for BA at our institution were included. The serum sodium concentration ([Na]) before and after surgery and the incidence of hyponatremia were compared between patients administered fluids with [Na] of 35\u2009mmol\/L (exHYPO group, 59 patients) and those with [Na] of 83\u2009mmol\/L (HALF group, 20 patients).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age of patients was 59\u2009days. There were no significant differences in the background or preoperative [Na] between groups. There was a significant decrease in [Na] on postoperative day 3 (POD3) in the exHYPO group compared with the preoperative [Na] value in the exHYPO group and the [Na] value on POD3 in the HALF group. There were no significant differences in [Na] before and after surgery in the HALF group. The odds ratio was 21.0, and the 95% confidence interval was 3.31\u2013130, indicating that the exHYPO group had an increased risk of hyponatremia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Administration of half saline as maintenance fluid can maintain [Na] levels during postoperative care of infants with BA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70016","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:34:34Z","timestamp":1747204474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyponatremia is not induced by postoperative hypotonic fluids in infants with biliary atresia after sufficient diuresis"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3473-2472","authenticated-orcid":false,"given":"Kazuki","family":"Yokota","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"},{"name":"Department of Pediatric Surgery Aichi Developmental Disability Center Central Hospital  Kasugai Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyoe","family":"Shirota","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Tainaka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Sumida","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Makita","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hizuru","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousuke","family":"Gohda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Aichi 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