{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:57:23Z","timestamp":1790913443077,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP17km0105001"],"award-info":[{"award-number":["JP17km0105001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21tm0124005"],"award-info":[{"award-number":["JP21tm0124005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19gk0110039\uff1aJP21tm0424601"],"award-info":[{"award-number":["JP19gk0110039\uff1aJP21tm0424601"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies investigating whether respiratory syncytial virus (RSV) infection, non\u2010RSV respiratory infections, respiratory\u2010related disorders, and non\u2010respiratory\u2010related disorders are associated with subsequent wheezing are limited in Japan. We aimed to elucidate the relationship between hospitalization for RSV infection, non\u2010RSV respiratory infections, respiratory\u2010related disorders, as well as non\u2010respiratory\u2010related disorders and subsequence wheezing in Japanese children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 7340 children and was conducted under the TMM BirThree Cohort Study (Tohoku Medical Megabank Project Birth and Three\u2010Generation Cohort Study). Data was collected from birth records and questionnaires. We categorized hospitalization history into five categories: \u201cno hospitalization,\u201d hospitalizations for \u201cRSV infection,\u201d \u201cnon\u2010RSV respiratory infections,\u201d \u201crespiratory\u2010related disorders,\u201d and \u201cnon\u2010respiratory\u2010related disorders.\u201d The association of the five categories with later wheezing at 3\u2009years of age was evaluated using multivariable logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After adjusting for covariates, an association was shown between hospitalization under 2\u2009years of age and later wheezing (odds ratio [OR]\u2009=\u20092.78; 95% confidence interval [CI]\u2009=\u20091.97\u20133.88 for \u201cRSV infection\u201d; OR\u2009=\u20092.61; 95% CI\u2009=\u20091.44\u20134.57 for \u201cnon\u2010RSV respiratory infections\u201d; and OR\u2009=\u20093.33; 95% CI\u2009=\u20092.43\u20134.54 for \u201crespiratory\u2010related disorders\u201d).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hospitalization of children under 2\u2009years of age for RSV infection as well as non\u2010RSV respiratory infections and respiratory\u2010related disorders were associated with subsequent wheezing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70050","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T05:41:06Z","timestamp":1748238066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Respiratory syncytial virus infection, non\u2010respiratory syncytial virus respiratory infections, and later wheezing"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-2209","authenticated-orcid":false,"given":"Ippei","family":"Takahashi","sequence":"first","affiliation":[{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genki","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"},{"name":"Department of Preventive Medicine and Epidemiology Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Epidemiology Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Epidemiology Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi","family":"Noda","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"},{"name":"Department of Preventive Medicine and Epidemiology Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"},{"name":"Department of Pharmaceutical Sciences Tohoku University Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Epidemiology Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Ishikuro","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"},{"name":"Department of Preventive Medicine and Epidemiology Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Obara","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology, Graduate School of Medicine Tohoku University  Sendai Japan"},{"name":"Department of Preventive Medicine and Epidemiology Tohoku Medical Megabank Organization, Tohoku University  Sendai Japan"},{"name":"Department of Pharmaceutical Sciences Tohoku University Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Nakayama","sequence":"additional","affiliation":[{"name":"R&amp;D Clinical Science Div Janssen Pharmaceutical K.K.  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