{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:29:24Z","timestamp":1791818964415,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":114,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Discussions regarding the treatment of acute bronchiolitis are ongoing. In this study, we investigated the effects of bronchodilators in infants with viral bronchiolitis using a lung sound analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Subjects were hospitalized children diagnosed with viral acute bronchiolitis who received inhaled short\u2010acting inhaled beta 2\u2010agonist (SABA). Lung sounds were collected before and after SABA inhalation, and imaged and quantified using a dedicated analysis system to objectively evaluate the effects of SABA. Furthermore, we investigated the influence of the child's clinical symptoms (clinical score, SpO\n                      <jats:sub>2<\/jats:sub>\n                      value, hospitalization days, etc.), past history and family history of allergic diseases on the changes in lung sounds after SABA inhalation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010six children (male: female\u2009=\u200916: 10, median age: 11\u2009months) participated in the study, and wheezes on the lung sound spectrogram disappeared or decreased after inhalation of SABA in 57.7% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915). However, no improvement in the low\u2010pitched sounds of the lung spectrogram was evident, and no significant change was observed in the exhalation\/inspiration power ratio. Although SpO\n                      <jats:sub>2<\/jats:sub>\n                      in the group whose wheezes improved due to SABA inhalation was significantly lower than that in the group without improvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), there were no significant differences in other factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The lung sound analysis confirmed that wheezes improved after SABA inhalation in half of the infants with acute viral bronchiolitis. However, since there was no improvement in clinical symptoms or low\u2010pitched sounds, it was hypothesized that respiratory dysfunctions were caused by various mechanisms in infants with acute bronchiolitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70053","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T06:45:17Z","timestamp":1745563517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the effect of inhaled \u03b2\n                    <sub>2<\/sub>\n                    agonist on lung sounds of children with acute bronchiolitis"],"prefix":"10.1111","volume":"67","author":[{"given":"Yu","family":"Kuramochi","sequence":"first","affiliation":[{"name":"Tokyo Metropolitan Children's Medical Center  Fuchu Tokyo 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