{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:57:22Z","timestamp":1790913442994,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":114,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bisphenol exposure during pregnancy has been linked to a range of adverse reproductive outcomes. However, the full extent of the effects of bisphenol analogs, particularly bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF), on fetal development, especially anogenital distance (AGD), a sensitive marker of reproductive development, remains unclear. We conducted this research to investigate association among maternal and neonatal urinary bisphenol analogs (BPA, BPS, BPF) and AGD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study enrolled 85 mother\u2010newborn pairs in Bangkok, Thailand, from April 2023 to January 2024. Maternal and neonatal urine samples were collected and analyzed for BPA, BPF, and BPS concentrations by liquid chromatography\u2010tandem mass spectrometry. Neonatal AGD measurements were obtained within 72\u2009h of birth. Correlation was analyzed by Pearson's correlation test and linear regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      High maternal urinary BPF concentrations were negatively associated with ano\u2010penile distance, ano\u2010scrotal distance, and penile length in male newborns (\n                      <jats:italic>r<\/jats:italic>\n                      \u22120.963, \u22120.844 and\u2009\u2212\u20090.900, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). No significant associations were found for BPA or BPS. Frequent maternal consumption of carton drinks was associated with higher neonatal BPS levels, while maternal obesity was positively correlated with maternal BPA concentration. No significant correlation was observed between maternal and neonatal bisphenol concentrations, nor between neonatal bisphenol levels and AGD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study is the first to report a negative association between maternal BPF exposure and AGD in male newborns. These findings highlight the potential endocrine\u2010disrupting effects of BPF on fetal development and emphasize the need for further research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70054","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:07:57Z","timestamp":1745564877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased maternal urinary bisphenol F levels associated with reduced anogenital distance in male newborns"],"prefix":"10.1111","volume":"67","author":[{"given":"Pongpol","family":"Jameekornkul","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattakarn","family":"Numsriskulrat","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Division of Academic Affairs, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suparb","family":"Aroonyaparkmongkol","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulthida","family":"Soongswang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Somdej Phra Pinklao Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3173-4133","authenticated-orcid":false,"given":"Vichit","family":"Supornsilchai","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine Chulalongkorn 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